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NIRAPARIB
SynDRA canonical compound SYN0021759 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | PARP1 | PARP2 |
|---|
| Mechanism of action | PARP inhibitor |
|---|
| Indication | primary peritoneal cancer (PPC) |
|---|
| Disease area | oncology |
|---|
All known targets
- PARP1
- PARP2
- PARP10
- PARP12
- PARP14
- PARP15
- PARP3
- PARP4
- TNKS
- TNKS2
Mechanisms of action (all sources)
- PARP2 INHIBITOR
- Poly [ADP-ribose] polymerase 2 inhibitor
- PARP1 INHIBITOR
- Poly [ADP-ribose] polymerase-1 inhibitor
- PARP inhibitor
- PARP1 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PARP8
- SLC6A4
- SLC6A3
- SLC6A2
- KCNH2
- DYRK1B
- PARP9
- DYRK1A
- PARP11
- HTR1A
- HTR2B
- MAOA
- OPRM1
- ACHE
- PARP16
- HDAC6
- PDE3A
- PDE4A
- PGR
- PTGS1
- TBXA2R
- HRH3
- F2
- GSK3B
- ADORA1
- ADRA1A
- ADRA2A
- AR
- CHRM1
- CHRM2
- CLK1
- CLK2
- CLK3
- CLK4
- CSNK1E
- CYP1A1
- DRD1
- DRD3
- DYRK2
- DYRK3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- COMT
- GAMT
- GNMT
- GPX1
- GPX4
- HNMT
- KSYK
- NNMT
- NSD2
- NTM1A
- NTMT1
- PNMT
- SYK
Drug classes
- Antineoplastic Agents
- Enzyme Inhibitors
- Poly(ADP-ribose) Polymerase Inhibitors
- Poly(ADP-Ribose) Polymerase Inhibitor
ATC classes
- L01X · OTHER ANTINEOPLASTIC AGENTS
Cross-references
Synonyms
- AKEEGA
- ZEJULA
- Zejula
- niraparib hydrochloride
- niraparib HCl
- MK-4827
- niraparib tosylate monohydrate
- niraparib tosylate
- zejula
- JNJ-64091742
- MK4827
- NIRAPARIB (MK-4827)
- ZL-2306
- MK 4827
- UNII-HMC2H89N35
- HMC2H89N35
- CHEMBL1094636
- Niraparib [USAN:INN]
- MK 4827 (Base)
- Niraparib (USAN)
- Zejula (TN)
- MK-4827(Niraparib)
- SCHEMBL1421875
- GTPL8275
- CTK8B9123
- EX-A290
- DTXSID50146129
- MolPort-023-219-142
- ZINC43206370
- BDBM50316226
- Niraparib Tosylate
- MK-4827 (tosylate)
- MK 4827 tosylate
- UNII-75KE12AY9U
- MK-4827(Niraparib) tosylate
- 75KE12AY9U
- Niraparib(MK-4827) tosylate
- KS-00000TSH
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