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GSK-1070916
SynDRA canonical compound SYN0021725 — structure-anchored drug synonym record
| Clinical phase | Phase 1 |
|---|
| Primary target(s) | AURKB |
|---|
| Mechanism of action | Aurora kinase inhibitor |
|---|
All known targets
- AURKB
- AURKC
- AURKA
- CYP2D6
- CYP3A4
Mechanisms of action (all sources)
- aurora kinase inhibitor
- AURKB INHIBITOR
- Serine/threonine-protein kinase Aurora-B inhibitor
- AURKC INHIBITOR
- Serine/threonine-protein kinase Aurora-C inhibitor
- AURKA INHIBITOR
- AURKB MODULATOR
- AURKC MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- MAPKAPK2
- RET
- MYLK3
- MAP2K5
- SYK
- NTRK1
- IKBKE
- CIT
- SIK2
- SIK1
- CSNK1D
- ROCK2
- RIPK2
- DCK
- TEK
- DDR1
- DDR2
- FLT4
- FLT3
- PTK6
- FLT1
- FGFR1
- PRKD3
- PRKD2
- FECH
- PLK4
- MAP3K11
- EPHB6
- ACVR1
- ACVR1B
- ACVR2B
- TGFBR1
- MAP3K4
- MAP4K4
- BMP2K
- ADCK1
- ACAD10
- TNK1
- AKT3
- MAPK14
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- COMT
- CP2C9
- CP2D6
- CP3A7
- GAMT
- GNMT
- HNMT
- IFNG
- INCENP
- KSYK
- NNMT
- NSD2
- PARP1
- PNMT
- TPX2
Cross-references
Synonyms
- GSK 1070916A
- GSK1070916
- GSK1070916A
- GSK 1070916
- 3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea
- 8VLB51V7HO
- N'-[4-[4-[2-[3-[(Dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl]phenyl]-N,N-dimethylurea
- CHEMBL1090479
- 3-[4-[4-[2-[3-[(dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethylpyrazol-3-yl]phenyl]-1,1-dimethylurea
- 3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea.
- UNII-8VLB51V7HO
- 3-(4-(4-(2-(3-((DIMETHYLAMINO)METHYL)PHENYL)-1H-PYRROLO(2,3-B)PYRIDIN-4-YL)-1-ETHYL-1H-PYRAZOL-3-YL)PHENYL)-1,1-DIMETHYLUREA
- N'-{4-[4-(2-{3-[(dimethylamino)methyl]phenyl}-1H-pyrrolo[2,3-b]pyridin-4-yl) 1-ethyl-1H-pyrazol-3-yl]phenyl}-N,N-dimethylurea
- compound 17k [PMID 20420387]
- GTPL8358
- SCHEMBL4305006
- CHEBI:91362
- DTXSID70241403
- EX-A021
- HMS3265K13
- HMS3265K14
- HMS3265L13
- HMS3265L14
- HMS3750K05
- ACT06827
- BCP02610
- BDBM50315769
- MFCD22420815
- NSC777445
- NSC800108
- s2740
- ZINC43170519
- AKOS005145558
- BCP9000733
- CCG-269759
- CS-0008
- NSC-777445
- NSC-800108
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