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BARDOXOLONE

SynDRA canonical compound SYN0021688 — structure-anchored drug synonym record

All known targets

• NOS2
• PPARG
• KEAP1
• NFE2L2

Mechanisms of action (all sources)

• KEAP1 BINDER
• PPARG PARTIAL AGONIST
• nuclear factor erythroid derived, like (NRF2) activator
• NOS2 INHIBITOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• KEAP1
• HDAC6
• MBOAT4
• MLKL
• RIPK1
• RIPK3

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• IFNG

Cross-references

• PubChem CID: 400010
• ChEMBL: CHEMBL1093059
• DrugBank: DB12651
• ChEBI: 177450
• KEGG: D09584
• TTD: D05SCE

Synonyms

• Bardoxolona
• CDDO
• RTA-401
• RTA401
• RTA 401
• 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid
• UNII-7HT68L8941
• 7HT68L8941
• (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxylic acid
• C31H41NO4
• 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic acid
• RTA 402
• CCDO;(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxylic acid
• NSC711193
• bardoxolone RTA 401
• CDDO(Bardoxolone; RTA 401)
• (+)-2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid
• Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-
• (4AS,6AR,6BS,8AR,12AS,14AR,14BS)-11-CYANO-2,2,6A,6B,9,9,12A-HEPTAMETHYL-10,14-DIOXO-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,12A,14,14A,14B-OCTADECAHYDROPICENE-4A-CARBOXYLIC ACID
• (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-hexadecahydropicene-4a(2H)-carboxylic acid
• BARDOXOLONE [MI]
• BARDOXOLONE [INN]
• Bardoxolone (USAN/INN)
• Bardoxolone [USAN:INN]
• BARDOXOLONE [USAN]
• BARDOXOLONE [WHO-DD]
• SCHEMBL954253
• GTPL2717
• CHEMBL1093059
• CHEBI:177450
• 2-cyano-3,9-dien-28-oic acid
• DTXSID001025273
• BCP04662
• EX-A1731
• ZINC6019135
• BDBM50096348
• MFCD07772296
• s6647
• AKOS032960362