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MRK-560
SynDRA canonical compound SYN0021684 — structure-anchored drug synonym record
| Clinical phase | Preclinical |
|---|
| Primary target(s) | APP |
|---|
| Mechanism of action | gamma secretase inhibitor |
|---|
All known targets
Mechanisms of action (all sources)
- gamma-secretase inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- SLC18A2
- PSEN1
- IKBKE
- SLC6A3
- CIT
- LATS2
- EGFR
- AKT1
- PHKG1
- PHKA2
- PDPK1
- PAK4
- PDGFRB
- PDGFRA
- PI4KB
- PAK6
- PAK5
- AAK1
- PAK3
- PIK3C2G
- PAK2
- PAK1
- OXSR1
- OPRM1
- OPRK1
- OPRD1
- OGG1
- NUAK2
- NUAK1
- PIK3C2B
- PIK3C3
- NTRK2
- PKN1
- PRKCD
- PRKACB
- PRKACA
- PRKAA2
- PRKAA1
- PNCK
- PLK4
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- APH1A
- APH1B
- CP2C9
- CP2D6
- CP3A7
- CYP2C9
- CYP3A4
- NCSTN
- PSEN2
- PSENEN
Drug classes
- Gamma Secretase Inhibitors and Modulators
Cross-references
Synonyms
- MRK_560
- RefChem:828397
- MRK560
- C19H17ClF5NO4S2
- SCHEMBL237758
- SCHEMBL237759
- SCHEMBL237760
- orb1308012
- SCHEMBL29358202
- BDBM28986
- WDZVWDXOIGQJIO-UJKQEGAGSA-N
- EX-A5360
- AKOS024457922
- cyclohexyl sulfone-based compound, 32
- EBC-414093
- FM65096
- SB19628
- MRF-0000011
- NCGC00371101-01
- HY-14174
- MS-29608
- CS-0003248
- G13674
- T16133
- IGD
Look up MRK-560 in the interactive SynDRA portal →