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VARENICLINE
SynDRA canonical compound SYN0021114 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CHRNA4 |
|---|
| Mechanism of action | Acetylcholine receptor agonist |
|---|
| Indication | smoking cessation |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- CHRNA4
- CHRNB2
- CHRNA7
- CHRNA3
- CHRNA1
- Chrna2
- Chrnb4
- Chrnb2
- Chrna7
- Chrna4
- Chrna3
- CHRND
Mechanisms of action (all sources)
- Acetylcholine receptor agonist
- CHRNB2 AGONIST
- Neuronal acetylcholine receptor; alpha4/beta2 agonist
- CHRNA4 AGONIST
- CHRNB2 PARTIAL AGONIST
- Neuronal acetylcholine receptor; alpha4/beta2 partial agonist
- CHRNA4 PARTIAL AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR1
- ACHE
- KCNH2
- MAOA
- MBD4
- MC3R
- MLNR
- MPG
- MUTYH
- NEIL1
- NR1I2
- NR3C1
- NTHL1
- OPRD1
- OPRM1
- PDE3A
- PDE4D
- PGR
- PPARG
- PTGS2
- SLC22A2
- SLC29A1
- SLC6A2
- SLC6A3
- SLC6A4
- SLCO1B1
- SLCO1B3
- SLCO2B1
- TBXA2R
- TDG
- TDP1
- KDR
- HTR3A
- ADORA1
- CHRM3
- ADORA2A
- ADORA3
- ADRA1A
- ADRA2A
- ADRA2B
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Cholinergic Agonists
- Cholinergic Agents
- Neurotransmitter Agents
- Nicotinic Agonists
- Smoking Cessation Agents
- Partial Cholinergic Nicotinic Agonists
- Partial Cholinergic Nicotinic Agonist
- Cholinergic Receptor Agonist
ATC classes
- N07B · DRUGS USED IN ADDICTIVE DISORDERS
- S01X · OTHER OPHTHALMOLOGICALS
Cross-references
Synonyms
- CHANTIX
- Chantix
- TYRVAYA
- Tyrvaya
- VARENICLINE TARTRATE
- champix
- chantix
- varenicline tartrate
- CP-526,555-18
- Vareniclina
- CP-526,555
- CP-526555
- CP 526555
- Champix (TN)
- Chantix (TN)
- Varenicline (INN)
- W6HS99O8ZO
- vareniclina
- vareniclinum
- CHEBI:84500
- RefChem:58779
- DTXCID80197326
- N07BA03
- DTXCID101030560
- VARENICLINE [INN]
- Varenicline [INN:BAN]
- UNII-W6HS99O8ZO
- Champix;
- HSDB 7591
- MFCD10001497
- Varenicline Impurity 38
- VARENICLINE [MI]
- VARENICLINE [HSDB]
- VARENICLINE [VANDF]
- VARENICLINE [MART.]
- US9284322, varenicline
- VARENICLINE [WHO-DD]
- SCHEMBL137144
Reported adverse events
- Depression
- Depressed mood
- Nausea
- Headache
- Hypersensitivity
- Rash
- Somnolence
- Angioedema
- Abnormal dreams
- Asthenia
- Constipation
- Dysgeusia
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