← SynDRA

PELITINIB

SynDRA canonical compound SYN0020717 — structure-anchored drug synonym record

All known targets

• EGFR
• ERBB2

Mechanisms of action (all sources)

• EGFR INHIBITOR
• Epidermal growth factor receptor erbB1 inhibitor
• EGFR MODULATOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• AAK1
• LCK
• FRK
• FYN
• GAK
• HCK
• ITK
• JAK2
• JAK3
• KDR
• LYN
• FGR
• MAP2K1
• MAP2K2
• MAP3K1
• MAP3K20
• MAP3K3
• MAP3K4
• MAP4K1
• MAP4K2
• FLT3
• FES
• CSF1R
• EIF2AK2
• CSNK1A1L
• CSNK1D
• CSNK1E
• DAPK3
• DCLK3
• DLK1
• DMPK
• DYRK1B
• EIF2AK4
• FER
• EPHA3
• EPHA5
• EPHA6
• EPHA8
• EPHB1
• EPHB4

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• COMT
• M3K20
• ST17A
• PNMT
• PMYT1
• PI42B
• NTMT1
• NTM1A
• NSD2
• NNMT
• MP2K1
• M4K5
• M4K4
• M4K3
• M3K4
• M3K12
• CP2C9
• KSYK
• KKCC2
• KC1E
• KC1D
• IFNG
• IFNB1
• HNMT
• HLAB
• GNMT
• GAMT
• E2AK4
• E2AK2
• CTRO
• TP53

Drug classes

• Antineoplastic Agents
• Protein Kinase Inhibitors

Cross-references

• PubChem CID: 6445562
• ChEMBL: CHEMBL607707
• DrugBank: DB05524
• ChEBI: 38927
• KEGG: D05399
• PDB: 93J
• TTD: D0S3PO

Synonyms

• EKB-569
• WAY-EKB-569
• EKI-569
• EKB 569
• Pelitinib (EKB-569)
• (E)-N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
• (E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
• X5DWL380Z6
• (2E)-N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-2-butenamide
• (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamide
• CHEBI:38927
• Pelitinib (EKB-569; WAY-EKB 569)
• (E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide
• MFCD09837868
• (E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
• (E)-N-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-3-cyano-7-ethoxy-quinolin-6-yl]-4-(dimethylamino)but-2-enamide
• 2-Butenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-, (2E)-
• Pelitinib [USAN]
• EKI 569
• Pelitinib [USAN:INN]
• UNII-X5DWL380Z6
• EKB569
• (2E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
• (2e)-n-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
• 93J
• PELITINIB [INN]
• Pelitinib (USAN/INN)
• Pelitinib - EKB-569
• 2-Butenamide, (E)-,
• PELITINIB [WHO-DD]
• SCHEMBL93756
• SCHEMBL93757
• MLS006010062
• CHEMBL607707
• GTPL7644
• BDBM31090
• cid_6445562
• EX-A061
• BCPP000118