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DESOXIMETASONE

SynDRA canonical compound SYN0020349 — structure-anchored drug synonym record

All known targets

• NR3C1
• ANXA1
• ESRRA
• ESRRB
• ESRRG
• PGR
• PLA2G1B

Mechanisms of action (all sources)

• NR3C1 AGONIST

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• NR1I2
• AR
• ABCB11
• MMP9
• MC5R
• MC4R
• MC3R
• MAPK3
• MAPK14
• MAPK1
• MAOA
• LMNA
• LCK
• KDR
• KCNH2
• HTR6
• HTR2C
• HTR2B
• HTR2A
• HTR1A
• HRH3
• HRH2
• HRH1
• HMGCR
• HIF1A
• GMNN
• GLP1R
• MMP1
• NPY1R
• NFE2L2
• FLT1
• TDP1
• TBXAS1
• TBXA2R
• TACR2
• TACR1
• SMN1
• SLC6A4
• SLC6A3
• SLC6A2

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• ANDR
• CFTR
• CP2C9
• CP2CJ
• GLI3
• KCMB1
• M3K3
• PRGR

Drug classes

• Corticosteroid Hormone Receptor Agonists
• Corticosteroid
• Anti-Inflammatory Agents
• Glucocorticoids
• Hormones

ATC classes

• D07A · CORTICOSTEROIDS, PLAIN
• D07X · CORTICOSTEROIDS, OTHER COMBINATIONS

Cross-references

• PubChem CID: 5311067
• ChEMBL: CHEMBL1766
• DrugBank: DB00547
• ChEBI: CHEBI:691037
• KEGG: D03697
• RxNorm: 3255
• Wikipedia: Desoximetasone
• TTD: D0CZ1Q
• LINCS BRD: BRD-K30697463

Synonyms

• TOPICORT
• TOPICORT LP
• Topicort
• deoxymethasone
• desoximethasone
• desoxymetasone
• desoxymethasone
• Desoximetasona
• Desoxymethasone
• A-41-304
• A-41304
• HOE-304
• J83.644C
• NSC-759189
• R-2113
• Stiedex
• Stiedex lp
• Stiedex lpn
• Topicort lp
• Desoximetasonum
• Topicort (TN)
• Topicort Emollient (TN)
• Desoximetasone (USP/INN)
• 9alpha-fluoro-16alpha-methyl-Delta(1)-corticosterone
• BRD-K30697463
• desoximetasone (usp impurity)
• R 2113
• A 41-304
• NSC 759189
• HOE 304
• desoximetasone (usp monograph)
• dexamethasone impurity f (ep impurity)
• desoximetasone (usp-rs)
• 4E07GXB7AU
• A 41304
• Topicort LP
• Desossimetasone

Reported adverse events

• Cushing's syndrome
• Perioral dermatitis
• Application site irritation
• Application site pruritus
• Application site dryness
• Milia
• Miliaria
• Hypertrichosis
• Skin atrophy