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DIGOXIN
SynDRA canonical compound SYN0020295 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ATP1A1 |
|---|
| Mechanism of action | ATPase inhibitor |
|---|
| Indication | atrial fibrillation (AF) | congestive heart failure |
|---|
| Disease area | cardiology |
|---|
All known targets
- ATP1A1
- ATP1A2
- ATP1A3
- ATP1B1
- ATP1B2
- ATP1B3
- ATP1A4
- FXYD2
- RORC
- ABCB1
- KCNH2
- Rorc
Mechanisms of action (all sources)
- ATPase inhibitor
- ATP1A1 INHIBITOR
- ATP1B2 INHIBITOR
- ATP1B1 INHIBITOR
- ATP1A2 INHIBITOR
- ATP1B3 INHIBITOR
- ATP1A3 INHIBITOR
- ATP1A4 INHIBITOR
- FXYD2 INHIBITOR
- SLCO4C1 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- NPY1R
- NPY2R
- ESR1
- SLCO1B1
- NR1I2
- DRD1
- OPRD1
- NR1H4
- NR3C1
- ABCB4
- NPC1
- OPRM1
- PAX8
- PDE3A
- PDE4D
- PDE5A
- PGR
- PKM
- OPRK1
- NFE2L2
- PPARG
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOB
- MAOA
- LMNA
- LCK
- IDH1
- PPARD
- PPP3CA
- HTR3A
- TACR2
- SLCO1A2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT5A
- NOD2
- MDM4
- MDR1
- MITF
- NCOA1
- NCOA2
- NCOA3
- NF2L2
- NOD1
- NR5A2
- A4
- NSD2
- OPRD
- OPRM
- PTBP1
- SC6A3
- STK33
- SYK
- TNF10
- MDM2
- KSYK
- KLF5
- INS
- ANDR
- ATXN2
- CFTR
- COT2
- CP19A
- CSTA
- EPAS1
- ESRRA
- GALR3
- GCR
- GEMI
- GLI3
- HIF1A
- HLAB
- IDHC
- IFNB1
Drug classes
- Cardiac Glycoside
- Anti-Arrhythmia Agents
- Cardiotonic Agents
- Cardiovascular Agents
- Enzyme Inhibitors
- Protective Agents
ATC classes
- C01A · CARDIAC GLYCOSIDES
Cross-references
Synonyms
- DIGOXIN PEDIATRIC
- Digitek
- Digox
- LANOXICAPS
- LANOXIN
- LANOXIN PEDIATRIC
- Lanoxin
- cardiogoxin
- digoxine
- Digoxine
- Digoxina
- Digoxinum
- Dynamos
- Fargoxin
- Lanocardin
- Mapluxin
- Natigoxin
- Rougoxin
- Stillacor-
- Toloxin
- Vanoxin
- NSC-95100
- Digamex
- Digoxin pediatric
- Lanoxicaps
- Lanoxin pediatric
- Lanoxin-125
- Lanoxin-pg
- 12beta-Hydroxydigitoxin
- Digossina
- Digosin
- Lanicor
- Digacin
- Dilanacin
- CHEBI:4551
- MLS000069819
- Lanacordin
Reported adverse events
- Thrombocytopenia
- Sinus bradycardia
- Ventricular arrhythmia
- Headache
- Nausea
- Abdominal pain
- Rash
- Vomiting
- Death
- Dizziness
- Tachycardia
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