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CLOFARABINE
SynDRA canonical compound SYN0020292 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | RRM2 |
|---|
| Mechanism of action | Ribonucleoside reductase inhibitor |
|---|
| Indication | acute lymphoblastic leukemia (ALL) |
|---|
| Disease area | hematologic malignancy |
|---|
All known targets
- POLA1
- RRM1
- RRM2
- POLD1
- POLE
- POLE3
- RRM2B
- POLA2
- POLD2
- POLD3
- POLD4
- POLE2
Mechanisms of action (all sources)
- Ribonucleoside reductase inhibitor
- POLA1 INHIBITOR
- DNA polymerase (alpha/delta/epsilon) inhibitor
- POLD4 INHIBITOR
- POLD3 INHIBITOR
- POLD1 INHIBITOR
- POLD2 INHIBITOR
- POLE INHIBITOR
- POLA2 INHIBITOR
- PRIM1 INHIBITOR
- PRIM2 INHIBITOR
- POLE2 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ADORA1
- NR1I2
- ESR1
- DRD2
- PDE4D
- PDE3A
- HTR2B
- HTR2C
- HTR3A
- KCNH2
- MAOA
- MC3R
- MC4R
- MLNR
- NPY1R
- NR3C1
- HTR1A
- OPRD1
- OPRK1
- OPRM1
- PGR
- PTGS2
- SLC29A1
- SLC6A2
- SLC6A3
- SLC6A4
- TBXA2R
- HTR2A
- HRH2
- HRH3
- ADORA2A
- ADORA3
- ADRA1A
- ADRA2A
- ADRA2B
- ADRA2C
- ADRB1
- ADRB2
- AGTR1
- AVPR1A
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- ATXN2
- CP19A
- CREB1
- ESRRA
- GLI3
- IFNG
- KSYK
- NF2L2
- NSD2
- PARP1
- SYK
- TP53
Drug classes
- Nucleic Acid Synthesis Inhibitors
- Nucleoside Metabolic Inhibitor
- Antimetabolites
- Antimetabolites, Antineoplastic
- Antineoplastic Agents
- Noxae
ATC classes
Cross-references
Synonyms
- CLOLAR
- Clolar
- ivozall
- clofarex
- clolar
- evoltra
- Clofarabina
- NSC-759857
- Evoltra
- Ivozall
- CAFdA
- CFB
- Clofarabinum
- Clofarex
- Clofarabine [USAN]
- Clolar (TN)
- Evoltra (TN)
- Clofarabine (USAN/INN)
- Clolar, Evoltra, Clofarabine
- Cl-F-Ara-A
- 2-Cl-2'-F-araA
- 2-chloro-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)adenine
- 3S211048
- C1-F-Ara-A
- CHEBI:681569
- 762RDY0Y2H
- NSC 759857
- clofarabina
- clofarabinum
- Cl-F-araA
- MFCD00871077
- CAS-123318-82-1
- UNII-762RDY0Y2H
- Clofarabine [USAN:INN:BAN]
- NCGC00164553-01
- CLOFARABINE [MI]
- CLOFARABINE [INN]
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