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TIRBANIBULIN
SynDRA canonical compound SYN0020264 — structure-anchored drug synonym record
| Clinical phase | Phase 3 |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | SRC |
|---|
| Mechanism of action | SRC inhibitor | tubulin polymerization inhibitor |
|---|
All known targets
Mechanisms of action (all sources)
- SRC inhibitor
- Tyrosine-protein kinase SRC inhibitor
- tubulin polymerization inhibitor
- tyrosine kinase inhibitor
- TUBB INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABL1
- SYK
- BCR
- PAK2
- PDXK
- PDGFRB
- PCYT1A
- PASK
- PAK4
- PAICS
- PFKP
- OPA1
- OLA1
- NUAK2
- NTRK1
- NQO2
- NLK
- NEK9
- PEBP1
- PGRMC1
- NEK3
- PLK4
- PRKCA
- PRKAR2A
- PRKAG2
- PRKAG1
- PRKACB
- PRKACA
- PRKAA1
- PLK1
- PHKG2
- PKN2
- PKN1
- PKMYT1
- PIP4K2C
- PIP4K2A
- PIM2
- PIM1
- NEK7
- NEK2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- KSYK
- MITF
- TUBB6
- TUBB4B
- TUBB4A
- TUBB3
- TUBB2B
- TUBB2A
- TUBB1
- TUBA4A
- TUBA3E
- TUBA3C
- TUBA1C
- TUBA1B
- TUBA1A
- TFE3
- NSD2
- TUBB8
Drug classes
- Enzyme Inhibitors
- Microtubule Inhibitor
ATC classes
- D06B · CHEMOTHERAPEUTICS FOR TOPICAL USE
Cross-references
Synonyms
- KLISYRI
- Klisyri
- tirbanibulin mesylate
- KX01
- KX-01
- KX2-391
- klisyri
- ALM-14789
- Tirbanibuline
- Tirbanibulina
- KX-2-391
- KX-2391
- KX2391
- KX 01
- UNII-4V9848RS5G
- CHEMBL571546
- 4V9848RS5G
- MLS006011272
- SCHEMBL153779
- GTPL7957
- DTXSID30237862
- MolPort-023-293-512
- HUNGUWOZPQBXGX-UHFFFAOYSA-N
- HMS3656J15
- EX-A2434
- BCP02845
- ZINC43152787
- s2700
- BDBM50303801
- AKOS027276392
- SB16619
- CS-0248
- KX2-391 (KX01)
- BCP9000828
- NCGC00346644-05
- NCGC00346644-01
- KX 2
- KX2.391
Reported adverse events
- Application site pain
- Application site pruritus
- Erythema
- Swelling
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