← SynDRA

LY-2334737

SynDRA canonical compound SYN0020179 — structure-anchored drug synonym record

All known targets

• RRM2

Mechanisms of action (all sources)

• ribonucleotide reductase inhibitor
• RRM2 MODULATOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• HDAC6

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• CP2C9
• KSYK
• NSD2
• SYK

Drug classes

• antitumor agent

Cross-references

• PubChem CID: 11646777
• ChEMBL: CHEMBL577711
• DrugBank: DB12906
• TTD: D0F2JY
• LINCS BRD: BRD-K04993719

Synonyms

• LY2334737
• Gem prodrug (cancer), Eli Lilly
• Gemcitabine prodrug (cancer), Lilly
• LY 2334737
• Cytidine, 2'-deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)-
• YLR364XYSA
• N-[1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]-2-propylpentanamide
• UNII-YLR364XYSA
• SCHEMBL595762
• CHEMBL577711
• DTXSID001025742
• ZINC35996916
• BL98401
• CS-1815
• DB12906
• NCGC00378563-01
• NCGC00378563-02
• HY-13672
• LY 2334737;LY-2334737
• Q27294578
• 2'-Deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)-cytidine
• 1-(2,2-difluoro-2-deoxy-beta-D-ribofuranosyl)-4-(2-propyl-1-oxopentyl)aminopyrimidin-2-one
• RefChem:154538
• Gemcitabine Prodrug LY2334737
• 2'-Deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)cytidine
• orb1303216
• C17H25F2N3O5
• JXRHGMJVKRFLOK-UXIGCNINSA-N
• GLXC-90429
• EX-A8467
• AKOS030526967
• DA-65141
• MS-26471
• NS00072176
• T4061
• BRD-K04993719-001-01-7
• MEOYFIHNRBNEPI-UHFFFAOYSA-N