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RAF-265
SynDRA canonical compound SYN0020056 — structure-anchored drug synonym record
| Clinical phase | Phase 2 |
|---|
| Primary target(s) | BRAF | KDR | KIT | PDGFRB | RAF1 |
|---|
| Mechanism of action | RAF inhibitor | VEGFR inhibitor |
|---|
All known targets
Mechanisms of action (all sources)
- BRAF INHIBITOR
- Serine/threonine-protein kinase B-raf inhibitor
- KDR INHIBITOR
- Vascular endothelial growth factor receptor 2 inhibitor
- RAF inhibitor
- VEGFR inhibitor
- KDR MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- MAP4K4
- MAP3K20
- RIPK1
- RIPK2
- HIPK4
- CSF1R
- PDGFRA
- CIT
- PAK3
- LCK
- SRC
- CDK19
- LYN
- STK10
- NEK5
- STK25
- MAP2K5
- MAP3K11
- STK36
- HCK
- RET
- PTK6
- EIF2AK4
- PRKAA1
- EPHA8
- EPHA6
- EPHA4
- EPHA2
- EPHA1
- FER
- EIF2AK2
- DDR1
- FGFR1
- FLT1
- FLT3
- FLT4
- FRK
- FYN
- DDR2
- MAP3K19
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CTRO
- E2AK2
- E2AK4
- IFNG
- KSYK
- M3K20
- M4K4
- M4K5
- NSD2
- PGFRA
- PGFRB
- VGFR1
- VGFR3
Cross-references
Synonyms
- CHIR-265
- NVP-RAF265
- RAF265
- CHIR 265
- RAF265 (CHIR-265)
- 1-Methyl-5-[[2-[5-(trifluoromethyl)-1h-imidazol-2-yl]-4-pyridinyl]oxy]-n-[4-(trifluoromethyl)phenyl]-1h-benzimidazol-2-amine
- CHIR265
- RAF265(CHIR-265)
- UNII-8O434L3768
- 8O434L3768
- 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine
- 1-Methyl-5-({2-[5-(Trifluoromethyl)-1h-Imidazol-2-Yl]pyridin-4-Yl}oxy)-N-[4-(Trifluoromethyl)phenyl]-1h-Benzimidazol-2-Amine
- PubChem22594
- RAF 265
- RAF-265 (CHIR-265)
- 1-Methyl-5-((2-(5-(trifluoromethyl)-1H-imidazol-2-yl)-4-pyridinyl)oxy)-N-(4-(trifluoromethyl)phenyl)-1H-benzimidazol-2-amine
- 1-Methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]-oxy]-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine
- SCHEMBL686452
- CHEMBL558752
- GTPL5674
- RAF 265 [WHO-DD]
- BDBM31088
- CHEBI:91451
- EX-A072
- cid_11656518
- DTXSID601025871
- HMS3655B06
- HMS3672I21
- AMY24172
- RAF265 - CHIR-265
- MFCD16659061
- NSC754357
- NSC800861
- s2161
- ZINC18710085
- CHIR 265 (RAF 265)
- AKOS025117575
- CCG-264703
Look up RAF-265 in the interactive SynDRA portal →