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DIHYDROERGOTAMINE
SynDRA canonical compound SYN0019498 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ADRA2A | DRD2 | HTR1B | HTR1D | HTR1E | HTR1F | HTR2B | HTR7 |
|---|
| Mechanism of action | serotonin receptor agonist |
|---|
| Indication | migraine headache |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- HTR1D
- DRD2
- HTR1E
- HTR1F
- HTR2B
- HTR1B
- ADRA2A
- HTR7
- Htr6
- Htr1b
- Htr1a
- Htr7
Mechanisms of action (all sources)
- HTR1D AGONIST
- Serotonin 1d (5-HT1d) receptor agonist
- serotonin receptor agonist
- DRD2 AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HRH2
- APLNR
- OPRM1
- PDE4D
- DRD4
- DRD5
- SIGMAR1
- GHSR
- GLP1R
- FFAR4
- ADRB3
- ADRB2
- TMEM97
- GPR119
- MAOA
- MPHOSPH8
- HTR3A
- NTHL1
- KCNH2
- NR3C1
- NPY2R
- NPY1R
- NPSR1
- LCK
- NEIL2
- NEIL1
- MMP1
- MMP9
- LMNA
- MLNR
- MC5R
- MC4R
- OGG1
- MC3R
- MAPT
- MAPK3
- MAPK14
- MAPK1
- NTSR1
- ABCB11
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT1B
- 5HT1E
- 5HT1F
- 5HT2A
- 5HT7R
- ACES
- ANDR
- CP2C9
- CP2CJ
- CP2D6
- CP3A4
- ESRRA
- NR1I2
- TSHR
Drug classes
- Analgesics
- Analgesics, Non-Narcotic
- Cardiovascular Agents
- Central Nervous System Agents
- Dopamine Agents
- Dopamine Agonists
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Sensory System Agents
- Vasoconstrictor Agents
- Ergotamine Derivative
ATC classes
- N02C · ANTIMIGRAINE PREPARATIONS
Cross-references
Synonyms
- ATZUMI
- Atzumi
- BREKIYA (AUTOINJECTOR)
- Brekiya
- D.H.E. 45
- DIHYDROERGOTAMINE MESYLATE
- EMBOLEX
- MIGRANAL
- Migranal
- TRUDHESA
- Trudhesa
- dihydroergotamine mesilate
- dihydroergotamine tartrate
- 9,10-Dihydroergotamine
- dihydroergotamine mesylate
- Dihidroergotamina
- 9,10-dihydroergotamine
- Neomigran
- MAP-0004
- MAP0004
- Migranal (TN)
- BRD-K72166146
- MAP 0004
- codergocrine mesilate impurity d (ep impurity)
- DHE
- Dihydroergotaminum
- Diidroergotamina
- Agit
- CHEBI:4562
- DTXCID4025614
- DHE ratiopharm
- Von Ct, Ergotam
- DHE Puren
- Dihydroergotamine-Sandoz
- RefChem:55021
- D Tamin retard L.U.T.
- N02CA01
- Levadex
Reported adverse events
- Asthenia
- Dizziness
- Nausea
- Pharyngitis
- Somnolence
- Vomiting
- Fatigue
- Paraesthesia
- Sinusitis
- Rhinitis
- Headache
- Migraine
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