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NISOLDIPINE
SynDRA canonical compound SYN0019292 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CACNA1S |
|---|
| Mechanism of action | Calcium channel blocker |
|---|
| Indication | hypertension |
|---|
| Disease area | cardiology |
|---|
All known targets
- CACNA1C
- CACNA1D
- CACNA1S
- CACNA1F
- CYP3A5
- SCN2A
- SCN1A
- KCNH2
- Cacna1d
- Cacna1c
- A1BG
- CYP1A2
Mechanisms of action (all sources)
- Calcium channel blocker
- CACNA1C BLOCKER
- Voltage-gated L-type calcium channel blocker
- CACNA1S BLOCKER
- CACNA1D BLOCKER
- CACNA1F BLOCKER
- CACNA1C ANTAGONIST
- CACNA1C GATING INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PDE3A
- PGR
- NR1I2
- ABCB11
- NR3C1
- DRD2
- DRD3
- ESR2
- ESR1
- OPRM1
- ADRB2
- SCN5A
- MC3R
- ABCB1
- MC4R
- MC5R
- MAPK14
- MLNR
- MMP1
- MAPK3
- MAOA
- MAPK1
- NPY1R
- LMNA
- LCK
- IDO1
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- MMP9
- OPRD1
- NPY2R
- SLC29A1
- VDR
- USP1
- TDP1
- TBXAS1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- AHR
- NF2L2
- KCMB4
- KCNQ1
- KSYK
- LRC26
- MDM2
- MDM4
- MDR1
- MLLT3
- MRGPRX1
- NSD2
- ANDR
- PLIN5
- PLK1
- PRGR
- PRMT1
- RARA
- SMAD2
- SMAD3
- SYK
- TARDBP
- KCMB2
- KCMB1
- KCMA1
- JUN
- CBX1
- CFTR
- CP19A
- CP1A2
- CP2C9
- CP2CJ
- CP2D6
- CP3A4
- CP3A7
- CREB1
- ESRRA
- GCR
- GEMI
- GLI3
Drug classes
- Calcium Channel Antagonists
- Dihydropyridine Calcium Channel Blocker
- Antihypertensive Agents
- Calcium Channel Blockers
- Calcium-Regulating Hormones and Agents
- Cardiovascular Agents
- Membrane Transport Modulators
- Vasodilator Agents
ATC classes
- C08C · SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Cross-references
Synonyms
- SULAR
- Sular
- BAY k-5552
- nisoldipin
- zadipina
- Nisoldipino
- Baymycard
- Geomatrix 16e
- Nisoldipin
- Nisoldipine (stn)
- BAY-K-5552
- NSC-759106
- Nisocor
- Syscor mr 10
- Syscor mr 20
- Syscor mr 30
- Nisoldipinum
- Syscor
- Zadipina
- Bay-k-5552
- Nisoldipino [INN-Spanish]
- Nisoldipinum [INN-Latin]
- Sular (TN)
- Nisoldipine (JAN/USAN/INN)
- Nisoldipine [USAN:BAN:INN:JAN]
- (+-)-nisoldipine
- BAY-k 5552
- NSC 759106
- 4I8HAB65SZ
- nisoldipine (usp-rs)
- (+-)-bay-k-5552
- DTXCID403371
- Nisoldipina
- Nisoldipine SR
- RefChem:56577
- CHEBI:7577
- C08CA07
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