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BENDROFLUMETHIAZIDE
SynDRA canonical compound SYN0018774 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · OTC |
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| Primary target(s) | SLC12A3 |
|---|
| Mechanism of action | Sodium/potassium/chloride transporter inhibitor |
|---|
| Indication | hypertension |
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| Disease area | cardiology |
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All known targets
- SLC12A3
- SLC12A1
- CA1
- CA2
- CA4
- KCNMA1
Mechanisms of action (all sources)
- Sodium/potassium/chloride transporter inhibitor
- SLC12A3 INHIBITOR
- Thiazide-sensitive sodium-chloride cotransporter inhibitor
- SLC12A3 BLOCKER
- SLC12A1 BLOCKER
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ADRB2
- SLC6A3
- ABCB11
- NPY1R
- MLNR
- MC4R
- MC3R
- MAOA
- LMNA
- KDM4E
- NR3C1
- KCNH2
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- NR1I2
- OPRD1
- HRH3
- OPRK1
- OPRM1
- PDE3A
- PDE4D
- PGR
- POLK
- PTGS2
- SAMHD1
- SLC29A1
- SLC6A2
- SLC6A4
- TARDBP
- HTR1A
- HRH2
- ADORA1
- CBX1
- ADORA2A
- ADORA3
- ADRA1A
- ADRA2A
- ADRA2B
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Thiazide Diuretic
- Antihypertensive Agents
- Cardiovascular Agents
- Diuretics
- Membrane Transport Modulators
- Natriuretic Agents
- Sodium Chloride Symporter Inhibitors
ATC classes
- C03A · LOW-CEILING DIURETICS, THIAZIDES
- DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION
Cross-references
Synonyms
- CORZIDE
- NADOLOL AND BENDROFLUMETHIAZIDE
- NATURETIN-10
- NATURETIN-2.5
- NATURETIN-5
- bendrofluazide
- benzhydroflumethiazide
- benzidroflumetiazide
- benzydroflumethiazide
- benzylhydroflumethiazide
- benzylrodiuran
- Bendroflumetiazida
- NSC-758229
- Aprinox
- Bendroflumethiazide component of corzide
- Berkozide
- Centyl
- Naturetin
- Naturetin-10
- Naturetin-2.5
- Naturetin-5
- Neo-bendromax 2.5
- Neo-bendromax 5
- Neo-naclex
- Urizide
- BHFT
- Bendrofluazide
- Bendroflumethazide
- Bendroflumethiazidum
- Bendroflumetiazide
- Bendrofumethiazide
- Bentride
- Benuron
- Benzhydroflumethiazide
- Benzydroflumethiazide
- Benzylhydroflumethiazide
- Benzylrodiuran
- Bristuric
Reported adverse events
- Agranulocytosis
- Bradycardia
- Bronchospasm
- Cardiac failure
- Dizziness
- Hypersensitivity
- Leukopenia
- Nausea
- Orthostatic hypotension
- Pemphigoid
- Peyronie's disease
- Purpura
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