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HYDROCORTISONE BUTYRATE
SynDRA canonical compound SYN0018762 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | NR3C1 |
|---|
| Mechanism of action | glucocorticoid receptor agonist |
|---|
| Indication | corticosteroid-responsive dermatoses | eczema |
|---|
| Disease area | dermatology |
|---|
All known targets
- NR3C1
- ANXA1
- NOS2
- NR3C2
- ESRRA
- ESRRB
- ESRRG
- SERPINA6
- KCNA1
- SHBG
- SLC47A1
- FNTA
Mechanisms of action (all sources)
- NR3C1 AGONIST
- Corticosteroid agonist
- NR3C1 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR1
- PGR
- NR3C2
- ADORA1
- OPRD1
- HTR2C
- HTR3A
- KCNH2
- MAOA
- MC3R
- MC4R
- MLNR
- NFE2L2
- NPY1R
- NR1I2
- OPRK1
- HTR2A
- OPRM1
- PDE3A
- PDE4D
- PIN1
- PTGS2
- SLC29A1
- SLC6A2
- SLC6A3
- SLC6A4
- SLCO1B1
- SLCO1B3
- HTR2B
- HTR1A
- ADORA2A
- HRH2
- ADORA3
- ADRA1A
- ADRA2A
- ADRA2B
- ADRA2C
- ADRB1
- ADRB2
- AGTR1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACM1
- ANDR
- ARHGAP35
- CFTR
- NSD2
- PRGR
Drug classes
- Corticosteroid Hormone Receptor Agonists
- Corticosteroid
- Dermatologic Agents
- Anti-Inflammatory Agents
ATC classes
- D07A · CORTICOSTEROIDS, PLAIN
- CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS
- S01B · ANTIINFLAMMATORY AGENTS
- A07E · INTESTINAL ANTIINFLAMMATORY AGENTS
- S01C · ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
- D07X · CORTICOSTEROIDS, OTHER COMBINATIONS
- A01A · STOMATOLOGICAL PREPARATIONS
- R01A · DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
- C05A · AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
- H02A · CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
- S02B · CORTICOSTEROIDS
- CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Cross-references
Synonyms
- LOCOID
- LOCOID LIPOCREAM
- Hydrocortisone 17-butyrate
- laticort
- Hydrocortisone 17alpha-butyrate
- Hydrocortisone-17-butyrate
- Cortisol 17-butyrate
- NSC-758433
- Locoid
- Locoid c
- Locoid crelo
- Locoid lipocream
- hydrocortisone butyrate (usp monograph)
- hydrocortisone butyrate (usp-rs)
- NSC 758433
- Hydrocortisone-17alpha-butyrate
- Locoid Lipocream
- H-17-B
- CHEBI:31674
- DTXCID2025896
- Aquax-H
- RefChem:55348
- MLS000028716
- Laticort
- Alfason
- Hycortate
- Lacoidon
- SMR000058859
- Bucort
- Lacoid
- MFCD00083364
- HB(sub 17)
- CAS-13609-67-1
- CORTISOL, 17-BUTYRATE
- H.17B
- EINECS 237-093-4
Reported adverse events
- Ototoxicity
- Cushingoid
- Sodium retention
- Hypertension
- Exophthalmos
- Tendon rupture
- Fluid retention
- Vertigo
- Perioral dermatitis
- Epidural lipomatosis
- Central serous chorioretinopathy
- Hypertrichosis
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