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LEUCOVORIN
SynDRA canonical compound SYN0018573 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Mechanism of action | folate receptor ligand |
|---|
| Indication | osteosarcoma |
|---|
| Disease area | oncology |
|---|
All known targets
Mechanisms of action (all sources)
- folate receptor ligand
- DHFR MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCC2
- NR3C1
- NPY2R
- NPY1R
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LCK
- KCNH2
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- HDAC6
- NR1I2
- OPRD1
- ABCC3
- OPRK1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SLCO1B3
- SLCO1B1
- SLC6A4
- SLC6A3
- SLC6A2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Antidotes
- Micronutrients
- Protective Agents
- Vitamin B Complex
- Vitamins
- Folate Analog
ATC classes
- V03A · ALL OTHER THERAPEUTIC PRODUCTS
Cross-references
Synonyms
- LEUCOVORIN CALCIUM
- LEUCOVORIN CALCIUM PRESERVATIVE FREE
- VYKOURA
- Vykoura
- WELLCOVORIN
- sodium folinate
- folinic acid
- calcium folinate
- leucovorin calcium
- folinic acid calcium salt
- folinic acid calcium
- wellcovorin
- folinic acid calcium salt pentahydrate
- Folinic acid
- 5-formyltetrahydrofolate
- 5-formyltetrahydrofolic acid
- Leucovorin Calcium
- Leucovorin Calcium Preservative Free
- Wellcovorin
- 5-Formyltetrahydrofolic acid
- Folinic acid-SF
- Welcovorin
- Acide folinique
- 5-Formyl-5,6,7,8-tetrahydrofolic acid
- folinate
- N5-Formyltetrahydrofolic acid
- 10-Formyl-7,8-dihydrofolic acid
- Leucal
- N5-Formyl-5,6,7,8-tetrahydrofolic acid
- Q573I9DVLP
- 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid
- CHEBI:15640
- (5-formyl-5,6,7,8-tetrahydropteroyl)glutamate
- HSDB 6544
- N-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid
- Leucoverin
- [3H]folinic acid
- NSC3590
Reported adverse events
- Nausea
- Stomatitis
- Vomiting
- Constipation
- Dermatitis
- Malaise
- Leukopenia
- Alopecia
- Fatigue
- Infection
- Lethargy
- Thrombocytopenia
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