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PANOBINOSTAT
SynDRA canonical compound SYN0016554 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | HDAC1 | HDAC2 | HDAC3 | HDAC4 | HDAC6 | HDAC7 | HDAC8 | HDAC9 |
|---|
| Mechanism of action | HDAC inhibitor |
|---|
| Indication | multiple myeloma |
|---|
| Disease area | hematologic malignancy |
|---|
All known targets
- HDAC1
- HDAC2
- HDAC3
- HDAC4
- HDAC6
- HDAC7
- HDAC8
- HDAC9
- HDAC10
- HDAC11
- HDAC5
- BRD4
Mechanisms of action (all sources)
- HDAC1 INHIBITOR
- Histone deacetylase inhibitor
- HDAC3 INHIBITOR
- HDAC6 INHIBITOR
- HDAC2 INHIBITOR
- HDAC5 INHIBITOR
- HDAC7 INHIBITOR
- HDAC8 INHIBITOR
- HDAC11 INHIBITOR
- HDAC4 INHIBITOR
- HDAC9 INHIBITOR
- HDAC10 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- TET3
- TET2
- TET1
- PIK3C3
- FOXO1
- EZH2
- SIRT7
- SIRT3
- SIRT2
- SIRT1
- PIK3CG
- PIK3CB
- LTA4H
- CYP1A1
- CYP1A2
- CYP3A5
- CYP3A4
- CYP2E1
- CYP2D6
- CYP2C9
- CYP2C8
- CYP2C19
- CYP2C18
- CYP2B6
- CYP2A6
- CYP1B1
- CYP4A11
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ABCB5
- COMT
- GAMT
- GNMT
- HLAB
- HNMT
- IFNB1
- IFNG
- KSYK
- MDR1
- NCOR2
- NNMT
- NSD2
- PARP1
- PNMT
- SYK
Drug classes
- Histone Deacetylase Inhibitors
- Histone Deacetylase Inhibitor
- Antineoplastic Agents
- Enzyme Inhibitors
- Cytochrome P450 2D6 Inhibitors
ATC classes
- L01X · OTHER ANTINEOPLASTIC AGENTS
Cross-references
Synonyms
- FARYDAK
- Farydak
- farydak
- panobinostat lactate
- panobinostat lactate anhydrous
- LBH-589
- LBH589
- Panobinostat hydrate
- Faridak
- LBH-589B
- NVP-LBH589
- NVP-LBH-589
- Panobinostat, NVP-LBH589, LBH589
- LBH 589
- Panobinostat (LBH589)
- NVP-LBH 589
- Panobinostat(LBH589)
- CHEBI:85990
- 9647FM7Y3Z
- 404950-80-7 (free base)
- Farydak (TN)
- Panobinostat [INN]
- Panobinostat [USAN:INN]
- UNII-9647FM7Y3Z
- PANOBINOSTAT [MI]
- LBH589 - Panobinostat
- Panobinostat (USAN/INN)
- PANOBINOSTAT [USAN]
- PANOBINOSTAT [MART.]
- MLS006011216
- PANOBINOSTAT [WHO-DD]
- SCHEMBL164801
- SCHEMBL183197
- CHEMBL483254
- GTPL7489
- SCHEMBL22773814
- BDBM29589
- CHEBI:93774
Reported adverse events
- Arrhythmia
- ECG
- Fatigue
- Infection
- Neutropenia
- Thrombocytopenia
- Weight decreased
- Decreased appetite
- Asthenia
- Blood creatinine increased
- Death
- Hepatotoxicity
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