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TOREMIFENE

SynDRA canonical compound SYN0016431 — structure-anchored drug synonym record

All known targets

• ESR1
• ESR2
• CYP3A5
• ESRRG
• GP
• HTR6

Mechanisms of action (all sources)

• ESR2 MODULATOR
• ESR1 MODULATOR
• ESR1 ANTAGONIST
• selective estrogen receptor modulator (SERM)

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• ABCB1
• DHCR24
• EBP
• EHMT2
• GMNN
• HDAC6
• HNF4A
• KDM4A
• LMNA
• PLIN1
• SAMHD1
• TDP1
• USP1

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• 5HT2A
• IFNG
• SYK
• RARA
• PPP1CA
• PLIN5
• NR1I2
• M4K2
• KSYK
• KCNQ1
• KCNH2
• KCMB2
• KCMB1
• JUN
• GLI3
• ADRB2
• GEMI
• ESRRA
• DRD3
• DRD2
• CP3A4
• CP2D6
• CP2CJ
• CP2C9
• CP19A
• CASP7
• CASP3
• ANDR
• TSHR

Drug classes

• Selective Estrogen Receptor Modulators
• Estrogen Agonist/Antagonist
• Antineoplastic Agents
• Antineoplastic Agents, Hormonal
• Bone Density Conservation Agents
• Estrogen Receptor Modulators
• Hormone Antagonists

ATC classes

• L02B · HORMONE ANTAGONISTS AND RELATED AGENTS

Cross-references

• PubChem CID: 3005573
• ChEMBL: CHEMBL1655
• DrugBank: DB00539
• ChEBI: CHEBI:9635
• KEGG: D00967
• RxNorm: 38409
• PDB: T0R
• Wikipedia: Toremifene
• TTD: D04VFJ

Synonyms

• FARESTON
• Fareston
• TOREMIFENE CITRATE
• FC1157a
• FC 1157a
• fareston
• chlortamoxifen
• toremifene citrate
• Toremifeno
• Acapodene
• Chlortamoxifen
• Farestone
• Toremiphene
• GTX-006
• J33.157K
• Estrimex
• Toremifenum
• Toremifene Base
• Toremifeno [Spanish]
• Toremifenum [Latin]
• GTx-006
• Acapodene (TN)
• FC-1157a
• Fareston (TN)
• Toremifene (INN)
• Toremifene [INN:BAN]
• Z-Toremifene
• GTX-006 (Acapodene)
• Toremifene Citrate (1:1)
• (E)-Toremifene
• 7NFE54O27T
• CHEBI:9635
• 89778-26-7 (free base)
• TOREMIFENE [INN]
• UNII-7NFE54O27T
• CCRIS 8745
• TOREMIFENE [MI]
• TOREMIFENE [IARC]

Reported adverse events

• Torsade de pointes
• Dizziness
• Nausea
• Hepatotoxicity
• Vomiting
• Arrhythmia
• Cataract
• Diplopia
• Glaucoma
• Thrombophlebitis
• Thrombosis