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DOVITINIB
SynDRA canonical compound SYN0016425 — structure-anchored drug synonym record
| Clinical phase | Phase 3 |
|---|
| Primary target(s) | PDGFRB |
|---|
| Mechanism of action | VEGFR inhibitor |
|---|
All known targets
- FGFR3
- FLT1
- FLT3
- FLT4
- KDR
- KIT
- PDGFRB
- PDGFRA
- EGFR
- FGFR1
- CSF1R
- FGFR2
Mechanisms of action (all sources)
- EGFR INHIBITOR
- FGFR inhibitor
- FLT3 INHIBITOR
- PDGFR inhibitor
- VEGFR inhibitor
- FGFR3 INHIBITOR
- Fibroblast growth factor receptor 3 inhibitor
- Tyrosine-protein kinase receptor FLT3 inhibitor
- KIT INHIBITOR
- Stem cell growth factor receptor inhibitor
- PDGFRB INHIBITOR
- Platelet-derived growth factor receptor inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- AAK1
- DCLK3
- GRK1
- PRKCQ
- GRK4
- GRK7
- GSK3B
- HCK
- HIPK1
- HIPK2
- HIPK3
- HUNK
- PRKAG2
- PRKAG1
- IKBKE
- IRAK1
- PRKAA2
- IRAK4
- ITK
- JAK1
- JAK2
- JAK3
- LATS1
- LATS2
- LCK
- LIMK1
- PRKAA1
- GAK
- FYN
- FRK
- DYRK2
- DDR1
- DDR2
- RPS6KA6
- RPS6KA5
- RPS6KA4
- RPS6KA3
- RPS6KA2
- DLK1
- RPS6KA1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- AAPK1
- MK08
- M3K11
- M3K12
- M3K20
- M4K2
- M4K3
- M4K4
- M4K5
- MK10
- KSYK
- MP2K1
- MP2K2
- NSD2
- PI42B
- PI51A
- ST17A
- ST17B
- M3K10
- KS6B1
- AAPK2
- KCC2G
- CSK21
- CSK22
- E2AK2
- E2AK4
- IFNG
- KC1D
- KCC2D
- KKCC2
- KS6A5
- KPCD
- KPCD2
- KPCD3
- KS6A1
- KS6A2
- KS6A3
- KS6A4
- TSSK1
Cross-references
Synonyms
- TKI-258
- CHIR-258
- GFKI-258
- NVP-TKI258
- TKI258
- Chir 258
- TKI 258
- 4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one
- CHIR258
- Dovitinib (TKI-258, CHIR-258)
- UNII-I35H55G906
- CHEMBL522892
- I35H55G906
- (3Z)-4-Amino-5-fluoro-3-[5-(4-methyl-1-piperazinyl)-1,3-dihydro-2H-benzimidazol-2-ylidene]-2(3H)-quinolinone
- C21H21FN6O
- 4-Amino-5-fluoro-3-(5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl)quinolin-2(1H)-one
- Dovitinib [INN]
- Dovitinib lactate
- CHEMBL4578973
- 4-amino-5-fluoro-3-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one
- 4-Amino-5-Fluoro-3-(6-(4-Methylpiperazin-1-yl)-1H-Benzo[D]Imidazol-2-yl)Quinolin-2(1H)-One
- 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-quinolin-2-one
- (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1,3-dihydrobenzimidazol-2-ylidene]quinolin-2-one
- 4-AMINO-5-FLUORO-3-[ 5- (4-METHYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOL-2-YL]QUINOLIN-2(1H)-ONE
- Dovitinib, Free Base
- 38O
- MFCD10565680
- TK-258
- Kinome_1513
- Dovitinib (TKI-258)
- DOVITINIB [WHO-DD]
- MLS006009991
- SCHEMBL172687
- GTPL5962
- SCHEMBL9975396
- SCHEMBL20399550
- BDBM25118
- CHEBI:91395
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