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VORAPAXAR
SynDRA canonical compound SYN0016089 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | F2R |
|---|
| Mechanism of action | thrombin inhibitor |
|---|
| Indication | myocardial infarction | peripheral artery disease (PAD) |
|---|
| Disease area | cardiology |
|---|
All known targets
Mechanisms of action (all sources)
- F2R ANTAGONIST
- Proteinase-activated receptor 1 antagonist
- thrombin inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB11
- GPR183
- ADORA3
- GPR35
- OPRM1
- SLC6A2
- KCNH2
- MAOA
- MUTYH
- MPG
- MBD4
- HTR2B
- KDR
- NEIL2
- HTR1A
- HRH3
- HDAC6
- NEIL1
- OGG1
- NTHL1
- GLP1R
- PDE3A
- PDE4A
- PGR
- PTGS1
- S1PR1
- SCN5A
- SLC6A3
- SLC6A4
- SMUG1
- TBXA2R
- TDG
- GPR119
- FPR2
- ACHE
- CYP1A2
- ADGRF1
- ADRA1A
- ADRA2A
- ADRB2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Hematologic Agents
- Platelet Aggregation Inhibitors
- Protease-activated Receptor-1 Antagonists
- Protease-activated Receptor-1 Antagonist
ATC classes
- B01A · ANTITHROMBOTIC AGENTS
Cross-references
Synonyms
- ZONTIVITY
- Zontivity
- SCH 530348
- SCH530348
- vorapaxar sulfate
- zontivity
- SCH-530348
- UNII-ZCE93644N2
- CHEMBL493982
- CHEBI:82702
- ZCE93644N2
- MK-5348
- Vorapaxar [USAN:INN]
- Sch 530348
- vorapaxarum
- RefChem:56276
- B01AC26
- DTXCID801436165
- Vorapaxar free base
- MFCD16038876
- MK 5348
- Vorapaxar [USAN]
- Vorapaxar?
- C29H33FN2O4
- Vorapaxar [INN]
- an-6-yl]carbamate
- Vorapaxar (Standard)
- VORAPAXAR [MI]
- Vorapaxar (USAN/INN)
- VORAPAXAR [VANDF]
- Vorapaxar (MK-5348)
- VORAPAXAR [MART.]
- VORAPAXAR [WHO-DD]
- MLS006010324
- SCHEMBL471187
- GTPL4047
- orb1300144
- Vorapaxar (SCH 530348)
Reported adverse events
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