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N,N-HEXAMETHYLENEAMILORIDE
SynDRA canonical compound SYN0014409 — structure-anchored drug synonym record
| Primary target(s) | SLC9A1 |
|---|
| Mechanism of action | Sodium/hydrogen antiport inhibitor |
|---|
All known targets
- GNRHR
- ADRA2A
- ADRA2C
- SLC9A1
Mechanisms of action (all sources)
- Sodium/hydrogen antiport inhibitor
- ADRA2A NEGATIVE ALLOSTERIC MODULATOR
- GNRHR NEGATIVE ALLOSTERIC MODULATOR
- GNRHR MODULATOR (ALLOSTERIC MODULATOR)
- ADRA2C MODULATOR (ALLOSTERIC MODULATOR)
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ADORA2A
- KCNH2
- PLAU
- SLC9A5
- SCN5A
- MPHOSPH8
- NPC1
- PLAT
- PLG
- PMP22
- PROC
- RAB9A
- RGS4
- SCNN1A
- LMNA
- SCNN1B
- SCNN1G
- SLCO1B1
- SMPD1
- TDP1
- THPO
- TP53
- TRPV1
- TSHR
- MBNL1
- KLKB1
- ALDH1A1
- KDM4A
- ALOX15B
- APEX1
- ARSA
- ASIC3
- ATAD5
- ATXN2
- BAZ2B
- CBX1
- CYP1A2
- CYP2C19
- CYP2C9
- CYP2D6
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ADORA2B
- CP1A2
- CP2CJ
- ESRRA
- KCNK3
- MRGPRX1
- OPRD
- OPRM
- SC5A7
- TADA2A
Drug classes
Cross-references
Synonyms
- 5-(N,N-hexamethylene)-amiloride
- 5-(N,N-Hexamethylene)amiloride
- Hexamethyleneamiloride
- Hexamethylene amiloride
- HMA-5
- HMA
- C12H18ClN7O
- 3-Amino-6-chloro-5-(1-homopiperidyl)-N-(diaminomethylene)pyrazinecarboxamide
- CHEBI:76400
- 3-amino-5-(azepan-1-yl)-6-chloro-N-(diaminomethylene)pyrazine-2-carboxamide
- 3-Amino-N-(aminoiminomethyl)-6-chloro-5-(hexahydro-1H-azepin-1-yl)pyrazinecarboxamide
- Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-(hexahydro-1H-azepin-1-yl)-
- 5-HMA
- Spectrum_001596
- hexamethyleneamiloride
- RefChem:531434
- DTXCID7084679
- 5-(N,N-hexamethylene)-Amiloride
- Hexamethylene amiloride;HMA
- RQQJJXVETXFINY-UHFFFAOYSA-N
- SpecPlus_000779
- Spectrum2_001669
- Spectrum3_001662
- Spectrum4_000623
- Spectrum5_001388
- Lopac-A-9561
- Lopac0_000104
- BSPBio_003443
- KBioGR_001206
- KBioSS_002076
- MLS002153208
- BIDD:GT0357
- DivK1c_006875
- SPECTRUM1504215
- SPBio_001857
- GTPL1192
- orb2893603
- SCHEMBL7862943
- SCHEMBL9852488
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