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OLAPARIB
SynDRA canonical compound SYN0014230 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | PARP1 |
|---|
| Mechanism of action | PARP inhibitor |
|---|
| Indication | ovarian cancer |
|---|
| Disease area | oncology |
|---|
All known targets
- PARP1
- PARP2
- PARP3
- PARP10
- PARP12
- PARP15
- PARP16
- PARP4
- PARP6
- TNKS
- TNKS2
Mechanisms of action (all sources)
- PARP inhibitor
- PARP1 INHIBITOR
- PARP 1, 2 and 3 inhibitor
- PARP3 INHIBITOR
- PARP2 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- CDK6
- TIPARP
- PARP11
- PARP14
- PARP8
- PARP9
- MC3R
- NPY1R
- NAMPT
- MLNR
- MC4R
- ABL1
- NR1I2
- MAOA
- KDR
- KCNH2
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- MAPK1
- OPRK1
- NR3C1
- OPRD1
- HRH1
- OPRM1
- PDE3A
- PDE4D
- PGR
- PIK3CA
- POLQ
- PTGS2
- SLC29A1
- SLC6A2
- SLC6A3
- SLC6A4
- TBXA2R
- HRH2
- HDAC1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Antineoplastic Agents
- Enzyme Inhibitors
- Poly(ADP-ribose) Polymerase Inhibitors
- Poly(ADP-Ribose) Polymerase Inhibitor
ATC classes
- L01X · OTHER ANTINEOPLASTIC AGENTS
Cross-references
Synonyms
- LYNPARZA
- Lynparza
- lynparza
- AZD2281
- AZ-2281
- AZ2281
- AZD-2281
- KU-0059436
- KU-59436
- KU0059436
- NSC-747856
- OLAPARIB (AZD2281)
- OLAPARIB COMPONENT OF KEYLYNK-010
- OLAPARIBAZD-2281AZD 2281KU 59436KU-59436LYNPARZAAZD2281KU59436O-9201
- Acylpiperazine analogue, 47
- Olaparib, KU-0059436, AZD2281,KU0059436, AZD2281
- AZD 2281
- KU 0059436
- Olaparib (AZD-2281)
- KU 59436
- Olaparib (AZD2281, Ku-0059436)
- MFCD13185161
- WOH1JD9AR8
- NSC 747856
- C24H23FN4O3
- CHEBI:83766
- KEYLYNK-010 COMPONENT OLAPARIB
- KU59436
- Olaparib [INN]
- OLAPARIB cpd
- Olaparib (AZD2281; Ku-0059436)
- Olaparib [USAN:INN]
- UNII-WOH1JD9AR8
- Olaparib (AZD2281)
- Olaparibum
- AZD221
- Olaparib- Bio-X
- Lynparza (TN)
Reported adverse events
- Cough
- Dizziness
- Dysgeusia
- Dyspepsia
- Erythema nodosum
- Fatigue
- Headache
- Hypersensitivity
- Leukopenia
- Lymphopenia
- Nausea
- Neutropenia
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