← SynDRA
CLEMASTINE
SynDRA canonical compound SYN0014227 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | HRH1 |
|---|
| Mechanism of action | Histamine receptor antagonist |
|---|
| Indication | allergic rhinitis | urticaria |
|---|
| Disease area | allergy |
|---|
All known targets
- HRH1
- ADRA1D
- ADRA2A
- SLC6A3
- SLC6A2
- SLC22A1
- SIGMAR1
- Pgrmc1
- KCNH2
- Htr1b
- HTR6
- HTR2C
Mechanisms of action (all sources)
- Histamine receptor antagonist
- HRH1 ANTAGONIST
- Histamine H1 receptor antagonist
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- OPRM1
- GHSR
- OPRK1
- HRH3
- ADRB2
- HTR1A
- NR1I2
- ESR2
- SLC6A4
- MTOR
- MMP1
- MMP9
- NPY2R
- NPY1R
- MC5R
- NR3C1
- OPRD1
- MLNR
- ACHE
- MC4R
- MC3R
- MAPK3
- MAPK1
- MAOA
- LCK
- IDH1
- HTR3A
- HNF4A
- HMGCR
- MAPK14
- PDE3A
- GPR35
- PDE4A
- TSHR
- TP53
- THPO
- TDP1
- TBXAS1
- TBXA2R
- TACR2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- GPR32
- SYK
- RARA
- PRGR
- NSD2
- MDR1
- KSYK
- JUN
- GLI3
- ACM1
- CP3A7
- CP3A4
- CP2D6
- CP2CJ
- CASP7
- CASP3
- ANDR
- TPO
Drug classes
- Anti-Allergic Agents
- Antipruritics
- Dermatologic Agents
- Histamine Agents
- Histamine Antagonists
- Histamine H1 Antagonists
- Neurotransmitter Agents
ATC classes
- R06A · ANTIHISTAMINES FOR SYSTEMIC USE
- D04A · ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
Cross-references
Synonyms
- CLEMASTINE FUMARATE
- TAVIST
- TAVIST ALLERGY/SINUS/HEADACHE
- TAVIST-1
- Tavist
- meclastine
- clemastine fumarate
- Clemastina
- Clemastin
- HS-592
- NSC-756685
- Clemastinum
- Meclastin
- Meclastine
- Mecloprodin
- Tavegyl
- Clemastina [INN-Spanish]
- Clemastine [USAN:BAN]
- Clemastinum [INN-Latin]
- Tavegyl (TN)
- Tavist (TN)
- Tavist (*Fumarate*)
- NSC 756685
- HS 592
- CHEBI:3738
- RefChem:56359
- DTXCID502832
- D04AA14
- R06AA04
- HS592
- C21H26ClNO
- MLS002154260
- CLEMASTINE [USAN]
- NCGC00016710-01
- SMR001233520
- CAS-14976-57-9
- UNII-95QN29S1ID
- Clemastine [USAN:INN:BAN]
Reported adverse events
Look up CLEMASTINE in the interactive SynDRA portal →