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LEVOTHYROXINE
SynDRA canonical compound SYN0014222 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | THRB |
|---|
| Mechanism of action | Thyroid hormone stimulant |
|---|
| Indication | myxedema coma |
|---|
| Disease area | endocrinology |
|---|
All known targets
- THRA
- THRB
- MDH2
- MIF
- NR1H4
- PPARG
- RXRA
- THAP1
- TTR
- Thrb
Mechanisms of action (all sources)
- Thyroid hormone stimulant
- THRA AGONIST
- Thyroid hormone receptor agonist
- THRB AGONIST
- THRA ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PGR
- SLCO1B1
- NR1I2
- UGT1A1
- SLCO4C1
- PDE4D
- SLCO1A2
- SLCO1C1
- RAPGEF3
- PTGS2
- PPARD
- POLK
- POLH
- PLK1
- ABCB1
- PIN1
- RXRG
- PDE3A
- PCNA
- OPRM1
- OPRK1
- OPRD1
- NR3C1
- RXRB
- SLC22A1
- SAMHD1
- SERPINA7
- UGT2B15
- UGT1A9
- UGT1A6
- UGT1A4
- TDP1
- SULT4A1
- SULT1B1
- SLCO4A1
- SLCO2B1
- SLCO1B3
- SLC6A4
- SLC6A3
- SLC6A2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ATG4B
- KCMB4
- PPP1CA
- PNMT
- PIP4K2A
- PAFA
- NNMT
- NF2L2
- MDR1
- KSYK
- KCMB2
- COMT
- KCMB1
- HNMT
- GNMT
- GCR
- GAMT
- CP3A7
- CP3A4
- CP2C9
- SYK
Drug classes
ATC classes
- H03A · THYROID PREPARATIONS
Cross-references
Synonyms
- ERMEZA
- EUTHYROX
- Ermeza
- Euthyrox
- LEVO-T
- LEVOLET
- LEVOTHYROXINE SODIUM
- LEVOXYL
- Levo-T
- Levoxyl
- SYNTHROID
- Synthroid
- levothyroxine sodium anhydrous
- levothyroxine sodium pentahydrate
- L-Thyroxine
- thyroxin sodium
- thyroxine sodium
- levothyroxine sodium
- tetraiodothyronine
- thyroxine
- levothyroxin natrium
- levothyroxine sodium hydrate
- L-thyroxine
- Levothyroxin
- Synthetic levothyroxine
- Thyroxine
- Thyroxine, l-
- NSC-36397
- SK&F 1-6528
- Eltroxin
- Forthyron
- Laevothyroxinum
- Laevoxin
- Levolet
- Levothroid
- Levothyrox
- Oroxine
- THX
Reported adverse events
- GH
- Hypersensitivity
- Seizure
- Choking
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