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MECLIZINE
SynDRA canonical compound SYN0014216 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | NR1I3 |
|---|
| Mechanism of action | CAR agonist |
|---|
| Indication | motion sickness | nausea | vomiting |
|---|
| Disease area | gastroenterology | neurology/psychiatry |
|---|
All known targets
Mechanisms of action (all sources)
- CAR agonist
- HRH1 ANTAGONIST
- Histamine H1 receptor antagonist
- NR1I3 ANTAGONIST
- constitutive androstane receptor (CAR) agonist
- NR1I3 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- OPRK1
- SLC6A3
- HTR2B
- HTR2A
- HRH2
- DRD4
- DRD3
- DRD2
- DRD1
- CNR1
- SLC6A2
- KCNH2
- ADRA2A
- ADRA2C
- ADORA3
- ADRA1A
- NEIL1
- NR5A1
- NR4A1
- NR3C1
- NR2E1
- NR2C1
- NPY2R
- NPY1R
- NFE2L2
- NEIL2
- MC4R
- MLNR
- NTSR1
- MC3R
- MBNL1
- MBD4
- MAPK1
- MAOA
- LMNA
- USP1
- KDR
- KDM4A
- NTHL1
- SMUG1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CP2C9
- KCNQ1
- PRKN
- NTMT1
- NTM1A
- NF2L2
- M4K2
- KSYK
- KCMB4
- CP2CJ
- KCMB1
- GEMI
- ESRRA
- CP3A7
- CP3A4
- CP2D6
- SYK
Drug classes
- Anti-Allergic Agents
- Antiemetics
- Central Nervous System Agents
- Cholinergic Agents
- Cholinergic Antagonists
- Gastrointestinal Agents
- Histamine Agents
- Histamine Antagonists
- Histamine H1 Antagonists
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Antiemetic
ATC classes
- R06A · ANTIHISTAMINES FOR SYSTEMIC USE
Cross-references
Synonyms
- ANTIVERT
- Antivert
- Bonine
- Dramamine Less Drowsy
- MECLIZINE HYDROCHLORIDE
- Pepto Nausea
- meclozine
- meclizine hydrochloride
- meclozine dihydrochloride
- meclizine HCl
- Meclozine
- Meclozina
- NSC-169189
- Ancolan
- Ancolon
- Bonadettes
- Calmonal
- Chiclida
- Diadril
- Histamethine
- Histamethizine
- Histametizine
- Histametizyn
- Histametizyne
- Itinerol
- Marex
- Meclicot
- Meclozinum
- Medivert
- Monamine
- Navicalm
- Nevidoxine
- Parachloramine
- Peremesin
- Postafene
- Ravelon
- Sabari
- Siguran
Reported adverse events
- Anaphylactic reaction
- Anaphylactoid reaction
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