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CLADRIBINE
SynDRA canonical compound SYN0014091 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ADA |
|---|
| Mechanism of action | Ribonucleoside reductase inhibitor |
|---|
| Indication | hairy cell leukemia |
|---|
| Disease area | hematologic malignancy |
|---|
All known targets
- ADA
- Adora1
- Adora2a
- DCK
- PDE4A
- PNP
- POLA1
- POLE
- POLE2
- POLE3
- POLE4
- RRM1
Mechanisms of action (all sources)
- Adenosine deaminase inhibitor
- Ribonucleoside reductase inhibitor
- ribonucleotide reductase inhibitor
- ADA INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PDE4D
- NR1I2
- ESR1
- DRD3
- MC4R
- OPRM1
- OPRK1
- OPRD1
- NR3C1
- NPY2R
- NPY1R
- NFE2L2
- MMP9
- MMP1
- MLNR
- MC5R
- ACHE
- PDE2A
- MBNL1
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- KCNH2
- IDH1
- HTT
- HTR6
- HTR3A
- MC3R
- PDE3A
- HTR2B
- PDE5A
- VIPR1
- TP53
- TDP1
- TBXAS1
- TACR2
- TACR1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- A4
- KSYK
- SMAD2
- RORA
- RARA
- NSD2
- MDM4
- MDM2
- JAK2
- CP1A2
- IFNG
- GLI3
- GALR3
- ESRRA
- CSTA
- CREB1
- SYK
Drug classes
- Purine Antimetabolite
- Antineoplastic Agents
- Immunologic Factors
- Immunosuppressive Agents
ATC classes
- L01B · ANTIMETABOLITES
- L04A · IMMUNOSUPPRESSANTS
Cross-references
Synonyms
- LEUSTATIN
- MAVENCLAD
- Mavenclad
- mavenclad
- litak
- cladarabine
- leustatin
- Cladribina
- 2-cda
- Cladaribine
- NSC-05014
- NSC-105014
- NSC-105014-F
- RWJ-26251
- Leustat
- Leustatin
- Litak
- Chlorodeoxyadenosine
- Cladarabine
- Cladribinum
- CldAdo
- Movectro;Mylinax
- CL9
- Leustatin (TN)
- Cladribine [USAN:INN:BAN]
- RWJ-26251-000
- Cladribine (JAN/USAN/INN)
- Leustatin, 2-chlorodeoxyadenosine, Cladribine
- Adenosine, 2-chloro-2'-deoxy
- 2-Chlorodeoxyadenosine
- 2'-Deoxy-2-chloroadenosine
- 2-CdA
- 2-Chloro-2'-deoxy-beta-adenosine
- 2-Chloro-2'-deoxyadenosine
- 2-chloro-deoxyadenosine
- 2 Chlorodeoxyadenosine
- 2CdA
Reported adverse events
- Teratogenicity
- Headache
- Hypersensitivity
- Infection
- Insomnia
- Alopecia
- Arthralgia
- Bronchitis
- Depression
- Hypertension
- Lymphopenia
- Nausea
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