← SynDRA

ALMOREXANT

SynDRA canonical compound SYN0011927 — structure-anchored drug synonym record

All known targets

• HCRTR1
• HCRTR2

Mechanisms of action (all sources)

• Orexin receptor antagonist
• HCRTR2 ANTAGONIST
• HCRTR1 ANTAGONIST

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• HDAC6

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• CP2C9
• CP2D6
• CP3A7
• KSYK
• NSD2
• SYK

Cross-references

• PubChem CID: 23727689
• ChEMBL: CHEMBL455136
• DrugBank: DB06673
• ChEBI: 177401
• KEGG: D09964
• Wikipedia: Almorexant
• TTD: D06BTF
• LINCS BRD: BRD-K84810405

Synonyms

• ACT-078573
• Almorexant [INN]
• (2R)-2-((1S)-6,7-dimethoxy-1-{2-(4-(trifluoromethyl)phenyl)ethyl}-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide
• (R)-2-((S)-6,7-Dimethoxy-1-(4-(trifluoromethyl)phenethyl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide
• Almorexant HCl
• 9KCW39P2EI
• CHEMBL455136
• Almorexant (INN)
• (2R)-2-[(1S)-6,7-dimethoxy-1-[2-[4-(trifluoromethyl)phenyl]ethyl]-3,4-dihydro-1H-isoquinolin-2-yl]-N-methyl-2-phenylacetamide
• (R)-2-((S)-6,7-diMethoxy-1-(4-(trifluoroMethyl)phenethyl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-Methyl-
• (R)-2-((R)-6,7-DIMETHOXY-1-(4-(TRIFLUOROMETHYL)PHENETHYL)-3,4-DIHYDROISOQUINOLIN-2(1H)-YL)-N-METHYL-2-PHENYLACETAMIDE
• UNII-9KCW39P2EI
• (2R)-2-((1S)-6,7-DIMETHOXY-1-(2-(4-(TRIFLUOROMETHYL)PHENYL)ETHYL)-3,4-DIHYDROISOQUINOLIN-2(1H)-YL)-N-METHYL-2-PHENYLACETAMIDE
• ALMOREXANT [MI]
• ALMOREXANT [WHO-DD]
• SCHEMBL196577
• GTPL2886
• CHEBI:177401
• BCPP000414
• DTXSID801007352
• BCP02616
• BDBM50292929
• MFCD22419385
• ZINC35953488
• AKOS016011276
• BCP9000275
• DB06673
• NCGC00378603-03
• AC-24400
• AS-17049
• HY-10805
• D09964
• Q4355941
• ((2r)-2-((1s)-6,7-dimethoxy-1-(2-(4-trifluoromethylphenyl)-ethyl)-3,4-dihydro-1h-isoquinolin-2-yl)-n-methyl-2-phenylacetamide)
• (2R)-2-[(1S)-6,7-dimethoxy-1-[2-[4-(triluoromethyl)phenyl]ethyl]-3,4-dihydro-1H-isoquinolin-2-yl]-N-methyl-2-phenylacetamide
• (2r)-2-{(1S)-6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-3,4-dihydro-1h-isoquinolin-2-yl}-n-methyl-2-phenyl-acetamide
• almorexantum
• RefChem:110942