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PITOLISANT
SynDRA canonical compound SYN0011887 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | HRH3 |
|---|
| Mechanism of action | histamine receptor antagonist |
|---|
All known targets
- HRH3
- HRH1
- HRH2
- BCHE
- HRH4
- Hrh3
- KCNH2
Mechanisms of action (all sources)
- HRH3 INVERSE AGONIST
- Histamine H3 receptor inverse agonist
- HRH1 ANTAGONIST
- HRH2 ANTAGONIST
- HRH3 ANTAGONIST
- HRH4 ANTAGONIST
- histamine receptor antagonist
- HRH3 AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- CHRM4
- TMEM97
- SLC6A4
- SLC6A3
- ADRA2C
- SLC6A2
- SIGMAR1
- HTR2C
- HTR7
- HTR6
- NEIL1
- MLNR
- MC3R
- MAOB
- MAOA
- ADGRF1
- HTR5A
- HTR3A
- NEIL2
- HTR2A
- HTR1E
- HTR1D
- HTR1B
- HTR2B
- NR3C1
- NPY1R
- PTGS2
- TSPO
- TDG
- TBXA2R
- SMUG1
- SCN5A
- S1PR1
- PGR
- NR1I2
- PDE4D
- PDE3A
- OPRM1
- OPRK1
- OPRD1
ATC classes
- N07X · OTHER NERVOUS SYSTEM DRUGS
Cross-references
Synonyms
- WAKIX
- Wakix
- HBS-101
- tiprolisant
- pitolisant hydrochloride
- tiprolisant hydrochloride
- wakix
- BF2.649
- Tiprolisant
- BF-2.649
- BF-2649
- Wakix, europe
- TIPROLISANT
- UNII-4BC83L4PIY
- 1-[3-[3-(4-chlorophenyl)propoxy]propyl]piperidine
- Pitolisant (BF2.649)
- 1-(3-(3-(4-Chlorophenyl)propoxy)propyl)piperidine
- 4BC83L4PIY
- Piperidine, 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-
- CHEMBL462605
- 1-[3-[3-(4-Chlorophenyl)propoxy]propyl]-piperidinehydrochloride
- 1-{3-[3-(4-chlorophenyl)propoxy]propyl}piperidine
- Tirolisant
- Pitolisant (INN)
- tiprolisant [USAN]
- Wakix (TN)
- Pitolisant [USAN:INN]
- SCHEMBL117648
- GTPL8924
- CTK1B6404
- Pitolisant [INN]
- Ozawade
- PIPERIDINE, 1-(3-(3-(4-CHLOROPHENYL)PROPOXY)PROPYL)-
- PITOLISANT [MI]
- Pitolisant (USAN/INN)
- PITOLISANT [USAN]
- PITOLISANT [WHO-DD]
- DTXSID30957654
Reported adverse events
- Abdominal pain
- Anxiety
- Cataplexy
- Dry mouth
- Hallucination
- Headache
- Heart rate
- Heart rate increased
- Insomnia
- Irritability
- Musculoskeletal pain
- Nausea
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