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METHYCLOTHIAZIDE
SynDRA canonical compound SYN0011738 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | SLC12A1 | SLC12A3 |
|---|
| Mechanism of action | chloride reabsorption inhibitor |
|---|
| Indication | edema | hypertension |
|---|
| Disease area | cardiology |
|---|
All known targets
Mechanisms of action (all sources)
- SLC12A3 INHIBITOR
- Thiazide-sensitive sodium-chloride cotransporter inhibitor
- chloride reabsorption inhibitor
- SLC12A1 BLOCKER
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- ADORA3
- TBXA2R
- SLC6A4
- SLC6A3
- SLC6A2
- PTGS1
- PGR
- PDE4A
- PDE3A
- OPRM1
- NFE2L2
- MAOA
- KDR
- KCNH2
- HTR2B
- HTR1A
- HRH3
- HDAC6
- GALC
- F2
- ESR1
- DRD3
- DRD1
- CHRM2
- CHRM1
- AR
- ADRA2A
- ADRA1A
- TDP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Thiazide Diuretic
- Diuretics
- Membrane Transport Modulators
- Natriuretic Agents
- Sodium Chloride Symporter Inhibitors
ATC classes
- C03A · LOW-CEILING DIURETICS, THIAZIDES
Cross-references
Synonyms
- AQUATENSEN
- DIUTENSEN-R
- ENDURON
- ENDURONYL
- ENDURONYL FORTE
- EUTRON
- METHYCLOTHIAZIDE AND DESERPIDINE
- methylclothiazide
- methychlothiazide
- methyclothiazid
- enduron
- Meticlotiazida
- NSC-110431
- Aquatensen
- Enduron
- Methyclothiazide component of diutensen-r
- Methyclothiazide component of enduronyl
- Methyclothiazide component of eutron
- Aquaresen
- Duretic
- Enduronum
- METHYLCLOTHIAZIDE
- Methychlothiazide
- Methyclothiazid
- Methyclothiazidum;Methycyclothiazide
- Methylchlorothiazide
- Methylcyclothiazide
- Meticlotiazide
- Naturon
- Meticlotiazide [DCIT]
- Ciba 7272-Su
- Enduron (TN)
- Methyclothiazidum [INN-Latin]
- Meticlotiazida [INN-Spanish]
- Naturon (VAN)
- Methyclothiazide (JAN/USP/INN)
- Methyclothiazide [USAN:INN:BAN:JAN]
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