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TENIPOSIDE
SynDRA canonical compound SYN0011657 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | CYP3A5 | TOP2A | TOP2B |
|---|
| Mechanism of action | topoisomerase inhibitor |
|---|
| Indication | acute lymphoblastic leukemia (ALL) |
|---|
| Disease area | hematologic malignancy |
|---|
All known targets
- TOP2A
- TOP2B
- ABCB1
- ABCC3
- ABCC6
- ABCG2
- CYP3A5
Mechanisms of action (all sources)
- TOP2A INHIBITOR
- DNA topoisomerase II inhibitor
- TOP2B INHIBITOR
- topoisomerase inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCC4
- KCNH2
- TBXA2R
- SLCO1B3
- SLCO1B1
- SLC6A4
- SLC6A3
- SLC6A2
- PTGS1
- PGR
- PDE4A
- PDE3A
- OPRM1
- MAOA
- KDR
- HTR2B
- ACHE
- HTR1A
- HRH3
- HDAC6
- F2
- ESR1
- DRD3
- DRD1
- CHRM2
- CHRM1
- AR
- ADRA2A
- ADRA1A
- ADORA3
- TOP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Topoisomerase Inhibitors
- Antineoplastic Agents
- Enzyme Inhibitors
- Topoisomerase II Inhibitors
- Topoisomerase Inhibitor
ATC classes
- L01C · PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
Cross-references
Synonyms
- VUMON
- tenoposide
- Teniposido
- NSC-122819
- VM-26
- VM26
- Vumon
- PTG
- Teniposidum
- Vehem
- Demethyl Epipodophyllotoxin Thenylidine Glucoside
- Teniposido [INN-Spanish]
- Teniposidum [INN-Latin]
- Vee M-26
- Veham-Sandoz
- Vumon (TN)
- Teniposide (USAN/INN)
- Teniposide [USAN:BAN:INN]
- VM-26 (TN)
- Vumon, VM-26, Vehem, NSC 122819, Teniposide
- 4'-Demethyl-epipodophyllotoxin-beta-D-thenylidene-glucoside
- 4'-Demethylepipodophyllotoxin thenylidene glucoside
- 4'-Demethylepipodophyllotoxin-beta-D-thenylidine glucoside
- VM 26
- Teniposide (Vumon)
- 957E6438QA
- HSDB 6546
- Teniposide [USAN]
- NSC122819
- CCRIS 2058
- EINECS 249-831-2
- Epidophyllotoxin
- Teniposide [USAN:INN:BAN]
- MFCD00866516
- UNII-957E6438QA
- Teniposide- Bio-X
- Epipodophyllotoxin-beta-D-thenylidene-glucoside, 4'-demethyl-
- TENIPOSIDE [MI]
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