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ATROPINE
SynDRA canonical compound SYN0010764 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CHRM5 |
|---|
| Mechanism of action | Acetylcholine receptor antagonist |
|---|
| Indication | amblyopia | cycloplegia | mydriasis |
|---|
| Disease area | ophthalmology |
|---|
All known targets
- CHRM1
- CHRM2
- CHRM3
- CHRM5
- CHRM4
- ADRA1D
- Chrm5
- SLC22A1
- HTR2C
- HTR2A
- HRH1
- GPM3
Mechanisms of action (all sources)
- Acetylcholine receptor antagonist
- CHRM3 ANTAGONIST
- Muscarinic acetylcholine receptor M3 antagonist
- CHRM1 ANTAGONIST
- Muscarinic acetylcholine receptor M1 antagonist
- CHRM2 ANTAGONIST
- Muscarinic acetylcholine receptor M2 antagonist
- CHRM5 ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCC2
- LCK
- NPY1R
- MMP9
- MMP1
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- KDR
- NR3C1
- KCNH2
- HTR6
- HTR2B
- HTR1A
- HRH3
- HRH2
- HMGCR
- GPR35
- GPR119
- GLP1R
- NPY2R
- OPRD1
- FPR2
- S1PR1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SLC6A4
- SLC6A3
- SLC6A2
- SLC47A2
- SLC47A1
- SIGMAR1
- PTPRC
- OPRK1
Drug classes
- Cholinergic Muscarinic Antagonists
- Cholinergic Antagonists
- Anticholinergic
- Adjuvants, Anesthesia
- Anti-Arrhythmia Agents
- Anti-Asthmatic Agents
- Bronchodilator Agents
- Cardiovascular Agents
- Central Nervous System Agents
- Cholinergic Agents
- Muscarinic Antagonists
- Mydriatics
ATC classes
- A03B · BELLADONNA AND DERIVATIVES, PLAIN
- S01F · MYDRIATICS AND CYCLOPLEGICS
- ANTISPASMODICS IN COMBINATION WITH PSYCHOLEPTICS
Cross-references
Synonyms
- ATNAA
- ATROPEN
- ATROPINE (AUTOINJECTOR)
- ATROPINE AND DEMEROL
- ATROPINE SULFATE
- Anaspaz
- Atropen
- COLONAID
- DI-ATRO
- DIPHENOXYLATE HYDROCHLORIDE AND ATROPINE SULFATE
- DIPHENOXYLATE HYDROCHLORIDE W/ ATROPINE SULFATE
- (+/-)-Atropine
- atropin
- atropinum sulphuricum
- DL-Hyoscyamine
- tropine tropate
- atropine sulfate
- Atropinum
- Dl-hyoscyamine
- Atroject
- Atrophate
- Atropine (autoinjector)
- Atropine component of atnaa
- Atropine component of duodote
- dl-Hyoscyamine
- Atropin
- dl-Tropyltropate
- Atropinol
- Atropina
- Eyesules
- Troyl tropate
- Atropin [German]
- Atropina [Italian]
- Atropin-flexiolen
- (+,-)-Tropyl tropate
- DL-Tropyl tropate
- Tropine, tropate (ester)
Reported adverse events
- Dehydration
- Hypersensitivity
- Photophobia
- Eye pain
- Constipation
- Anhidrosis
- Stevens-Johnson syndrome
- Glaucoma
- Coma
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