← SynDRA

CAPTOPRIL

SynDRA canonical compound SYN0010477 — structure-anchored drug synonym record

All known targets

• ACE
• LTA4H
• Ace
• F2
• MMP2
• MMP9
• PTGS1
• PTGS2
• REN
• SLC33A1
• bla2
• blaIMP-1

Mechanisms of action (all sources)

• ACE inhibitor
• SLC33A1 INHIBITOR
• SLC33A1 MODULATOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• DRD2
• HRH1
• MAOA
• NPY2R
• NPY1R
• MPHOSPH8
• MMP12
• MMP1
• MLNR
• MC5R
• MC4R
• MC3R
• MAPT
• MAPK3
• MAPK14
• MAPK1
• ABCB1
• NR3C1
• LMNA
• LCK
• KDM4E
• KCNH2
• HTR6
• HTR3A
• HTR2C
• HTR2B
• HTR2A
• HTR1A
• HSD17B10
• HRH3
• HRH2
• NR1I2
• OPRD1
• HDAC6
• OPRK1
• TRPV1
• THPO
• TF
• TBXAS1
• TARDBP

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• ACE2
• CP2CJ
• PSIP1

Drug classes

• Angiotensin-converting Enzyme Inhibitors
• Angiotensin Converting Enzyme Inhibitor
• Antihypertensive Agents
• Cardiovascular Agents
• Enzyme Inhibitors
• Protease Inhibitors

ATC classes

• C09A · ACE INHIBITORS, PLAIN
• ACE INHIBITORS, COMBINATIONS

Cross-references

• PubChem CID: 44093
• ChEMBL: CHEMBL1560
• DrugBank: DB01197
• ChEBI: CHEBI:3380
• KEGG: D00251
• RxNorm: 1998
• PDB: X8Z
• Wikipedia: Captopril
• TTD: D0I0EG
• LINCS BRD: BRD-K54529596

Synonyms

• CAPOTEN
• CAPOZIDE 25/15
• CAPOZIDE 25/25
• CAPOZIDE 50/15
• CAPOZIDE 50/25
• CAPTOPRIL AND HYDROCHLOROTHIAZIDE
• (-)-Captopril
• L-Captopril
• lopirin
• S-Captopril
• SQ14225
• SQ 14225
• Apopril
• Captomax
• Captoprilum
• Farcopril
• Garranil
• Hypopress
• Mepha
• Tensiomin
• Zapto
• C09AA01
• NSC-757419
• SA-333
• SQ-14225
• SQ 14,225
• Acepril
• Capoten
• Captomex
• Ecopace
• Hyteneze 12.5
• Hyteneze 25
• Hyteneze 50
• Kaplon
• Lopril
• Noyada
• Tensobon

Reported adverse events

• Angioedema
• Hypotension
• Cardiac arrest
• Myalgia
• Pruritus
• Tachycardia
• Angina pectoris
• Cough
• Flushing
• Neutropenia
• Rash
• Bronchospasm