← SynDRA

GUGGULSTERONE

SynDRA canonical compound SYN0009210 — structure-anchored drug synonym record

All known targets

• NR1H4

Mechanisms of action (all sources)

• estrogen receptor agonist, fxr antagonist, progesterone receptor agonist
• NR1H4 ANTAGONIST

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• NR3C2
• NR1I2
• NR3C1
• AR
• PGR
• PLA2G1B
• THRB
• SMN1
• RXRA
• RORC
• PPARG
• PPARD
• ALDH1A1
• NFE2L2
• KCNH2
• HIF1A
• HDAC6
• ESR1
• CYP3A4
• VDR

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• ANDR
• CP2C9
• CP2CJ
• CREB1
• ESR2
• ESRRA
• GCR
• GLI3
• NF2L2
• PRGR
• RARA
• TP53

Cross-references

• PubChem CID: 6450278
• ChEMBL: CHEMBL410683
• ChEBI: 135338
• Wikipedia: Guggulsterone
• TTD: D0G8BV

Synonyms

• Guggulsterone E
• (E)-Guggulsterone
• E-Guggulsterone
• Guggulsterones E
• trans-Guggulsterone
• Pregna-4,17-diene-3,16-dione
• UNII-9B259YE66O
• (17E)-Pregna-4,17(20)-diene-3,16-dione
• Z-Guggulsterone
• CHEMBL402063
• 9B259YE66O
• (8R,9S,10R,13S,14S,17E)-17-ethylidene-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione
• E-Guggulsteron
• Pregna-4,17(20)-diene-3,16-dione
• Guggulsterone, (E)-
• Guglip
• Z/E-Guggulsterone
• Pregna-4,17(20)-diene-3,16-dione, (17E)-
• Guggulsterones Z
• Cis-Guggulsterone
• (17E)-pregna-4,17-diene-3,16-dione
• (17Z)-Pregna-4,17(20)-diene-3,16-dione
• (17Z)-pregna-4,17-diene-3,16-dione
• (8R,9S,10R,13S,14S,17Z)-17-ethylidene-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione
• (Z)-Guggulsterone
• 4,17(20)-cis-Pregnadiene-3,16-dione
• gugulipid
• guggulipid
• RefChem:782937
• DTXCID60196615
• Guggulsterone E&Z
• GUGGULSTERONE Z
• Guggulsterone, (Z)-
• 6CST3U34GN
• Pregna-4,17(20)-diene-3,16-dione, (17Z)-
• Guggulsterone; Guglip; Gugulipid;
• MFCD01310757
• (17Z)-Guggulsterone