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ABIRATERONE ACETATE
SynDRA canonical compound SYN0009160 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CYP17A1 | CYP2C19 | CYP2C8 | CYP3A5 |
|---|
| Mechanism of action | androgen biosynthesis inhibitor |
|---|
| Indication | prostate cancer |
|---|
| Disease area | oncology |
|---|
All known targets
- CYP17A1
- AR
- CYP11B1
- CYP11B2
- CYP2C19
- CYP2C8
- CYP3A4
- CYP3A5
- Cyp17a1
Mechanisms of action (all sources)
- CYP17A1 INHIBITOR
- Cytochrome P450 17A1 inhibitor
- androgen biosynthesis inhibitor
- CYP17A1 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR1
- PGR
- ADORA1
- NR3C1
- HTR2A
- HTR2B
- HTR2C
- HTR3A
- KCNH2
- MAOA
- MC3R
- MLNR
- NR1I2
- OPRD1
- HRH3
- OPRM1
- PDE3A
- PDE4D
- PPARG
- PTGS2
- SCN5A
- SLC29A1
- SLC6A2
- SLC6A3
- SLC6A4
- HTR1A
- HRH2
- ADORA2A
- CCKAR
- ADORA3
- ADRA1A
- ADRA2A
- ADRA2B
- ADRA2C
- ADRB1
- ADRB2
- AGTR1
- AVPR1A
- CACNA1C
- CHRM1
Drug classes
- Antineoplastic Agents
- Cytochrome P-450 Enzyme Inhibitors
- Enzyme Inhibitors
- Hormone Antagonists
- Metabolic Side Effects of Drugs and Substances
- Steroid Synthesis Inhibitors
- Cytochrome P450 2D6 Inhibitors
- Cytochrome P450 17A1 Inhibitors
- Cytochrome P450 17A1 Inhibitor
- Cytochrome P450 2C8 Inhibitors
ATC classes
- HORMONE ANTAGONISTS AND RELATED AGENTS
Cross-references
Synonyms
- AKEEGA
- Abirtega
- Akeega
- YONSA
- Yonsa
- ZYTIGA
- zytiga
- CB-7630
- CB7630
- NSC-748121
- NSC-749227
- Abiraterone accord
- Abiraterone acetate component of akeega
- Abiraterone krka
- Abiraterone mylan
- Zytiga
- JNJ-212082
- BRD-K24048528
- abiraterone-acetate
- Abiraterone
- CB-7598
- 17-(3-Pyridyl)androsta-5,16-dien-3beta-ol
- Abiraterone (CB-7598)
- CB7598
- CHEMBL254328
- CHEBI:68642
- 154229-19-3 (Abiraterone)
- G819A456D0
- NSC 741232
- 17-(pyridin-3-yl)androsta-5,16-dien-3beta-ol
- Abiraterone [INN:BAN]
- UNII-G819A456D0
- Abiraterone- Bio-X
- MFCD00924100
- ABIRATERONE [MI]
- ABIRATERONE [INN]
- ABIRATERONE [VANDF]
Reported adverse events
- Cardiac failure
- Fracture
- Hypertension
- Hepatotoxicity
- Cardiac disorder
- Atrial fibrillation
- Angina pectoris
- Arrhythmia
- Bradycardia
- Dyspepsia
- Myalgia
- Tachycardia
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