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ALVIMOPAN
SynDRA canonical compound SYN0009109 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | OPRM1 |
|---|
| Mechanism of action | Opioid receptor antagonist |
|---|
| Indication | postoperative ileus |
|---|
| Disease area | gastroenterology |
|---|
All known targets
Mechanisms of action (all sources)
- Opioid receptor antagonist
- OPRM1 ANTAGONIST
- Mu opioid receptor antagonist
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- CACNA1C
- ACHE
- NTHL1
- KCND3
- KCNH2
- KDR
- MAOA
- MBD4
- MPG
- MUTYH
- NEIL1
- NEIL2
- PDE3A
- HTR1A
- PDE4A
- PGR
- PTGS1
- S1PR1
- SLC6A2
- SLC6A3
- SLC6A4
- TBXA2R
- TDG
- HTR2B
- HRH3
- ADGRF1
- CHRM2
- ADORA3
- ADRA1A
- ADRA2A
- ADRB2
- AGTR1
- APLNR
- AR
- C5AR1
- CHRM1
- CX3CR1
- HDAC6
- DRD1
- DRD3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Opioid Antagonists
- Gastrointestinal Agents
- Opioid Antagonist
ATC classes
- A06A · DRUGS FOR CONSTIPATION
Cross-references
Synonyms
- ENTEREG
- Entereg
- alvimopan dihydrate
- alvimopan anhydrous
- LY246736
- LY-246736
- entereg
- Alvimopan dihydrate
- Alvimopan anhydrous
- Anhydrous alvimopan
- ADL-8-2698
- LY-246736 DIHYDRATE
- LY 246736
- Adl 8-2698
- Entereg (TN)
- Trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine
- LY 246736 dihydrate
- anhydrous alvimopan
- Q153V49P3Z
- trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine
- alvimopanum
- ADL8-2698
- RefChem:111766
- DTXCID7088526
- A06AH02
- LY-246376
- Alvimopan [INN]
- MFCD09838268
- UNII-Q153V49P3Z
- ALVIMOPAN [MI]
- ALVIMOPAN [MART.]
- ALVIMOPAN [WHO-DD]
- SCHEMBL49578
- GTPL7471
- orb1309266
- Alvimopan, >=98% (HPLC)
- HSDB 7704
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