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LIOTHYRONINE
SynDRA canonical compound SYN0009060 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | THRB |
|---|
| Mechanism of action | Thyroid hormone stimulant |
|---|
| Indication | hypothyroidism | myxedema coma |
|---|
| Disease area | endocrinology |
|---|
All known targets
- THRA
- THRB
- ADORA1
- Gabrg1
- Gabra5
- Gabra6
- Gabrb1
- Gabrb2
- Gabrb3
- Gabrd
- Gabre
- Gabrg2
Mechanisms of action (all sources)
- Thyroid hormone stimulant
- THRA AGONIST
- Thyroid hormone receptor agonist
- THRB AGONIST
- THRA ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- SLCO4A1
- TTR
- NPY1R
- SLCO1A2
- SLCO4C1
- ESR2
- HNF4A
- ESR1
- SLCO1B1
- SLCO1B3
- NTSR1
- NR2E1
- PGR
- PDE5A
- PDE4D
- NPY2R
- NR1H4
- NR2C1
- NR3C1
- NTHL1
- NR4A1
- PDE3A
- OPRM1
- OPRK1
- OPRD1
- OGG1
- NR5A1
- ABCB1
- PLK1
- MC3R
- LMNA
- MAOA
- MAPK1
- MAPK14
- MAPK3
- MAPT
- MBD4
- MBNL1
- MC4R
- NPSR1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ATG4B
- COMT
- NR1I2
- NR4A2
- NR5A2
- PAFA
- PHGDH
- PIP4K2A
- PNMT
- PPP1CA
- PRGR
- PSDE
- RARA
- RARB
- RORA
- RORC
- SUMO1
- NNMT
- NF2L2
- HNMT
- ERR3
- CP2C9
- CP2CJ
- CP3A4
- CSTA
- DNMT1
- DPOLB
- ESRRA
- GPX4
- GAMT
- GCR
- GEMI
- GLSK
- GNMT
- GPR55
- TP53
Drug classes
ATC classes
- H03A · THYROID PREPARATIONS
Cross-references
Synonyms
- CYTOMEL
- Cytomel
- LIOTHYRONINE SODIUM
- TRIOSTAT
- liothyronine sodium
- triiodothyronine
- liothyronin
- Liotironina
- 3,5,3'-triiodothyronine, l-
- Cyronine
- Euthroid-0.5
- Euthroid-1
- Euthroid-2
- Euthroid-3
- Rathyronine, (s)-
- Thyrolar-0.25
- Thyrolar-0.5
- Thyrolar-1
- Thyrolar-2
- Thyrolar-3
- Thyrolar-5
- Triiodothyronine (t3 or liothyronine, active) (6-11%)
- NSC-80203
- Levothyroxine sodium related compound liothyronine
- 3,3',5-Triiodo-L-thyronine
- Liothyronin
- Tresitope
- 3,5,3'-triiodothyronine
- L-Liothyronine
- triothyrone
- Liothyroninum
- 3,5,3'-Triiodo-L-thyronine
- L-T3
- 3,3',5-Triiodothyronine
- Triiodo-L-thyronine
- Lyothyronine
- 3,5,3'TRIIODOTHYRONINE
- L-3,5,3'-Triiodothyronine
Reported adverse events
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