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AZATHIOPRINE
SynDRA canonical compound SYN0009026 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PPAT |
|---|
| Mechanism of action | Dehydrogenase inhibitor |
|---|
| Indication | renal homotransplantation | rheumatoid arthritis |
|---|
| Disease area | rheumatology | transplant |
|---|
All known targets
- PPAT
- ABCC4
- ABCC5
- ABCG2
- HPRT1
- IMPDH1
- PURA
- RAC1
- TPMT
Mechanisms of action (all sources)
- Dehydrogenase inhibitor
- PPAT INHIBITOR
- Amidophosphoribosyltransferase inhibitor
- PURA INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PGR
- ACHE
- MLNR
- MAPK3
- MAPT
- MBNL1
- MC3R
- MC4R
- MC5R
- MMP1
- MAPK1
- MMP9
- MPHOSPH8
- NFE2L2
- NPY1R
- NPY2R
- MAPK14
- MAOA
- NTSR1
- HTR2A
- HDAC6
- HMGCR
- HRH1
- HRH2
- HRH3
- HTR1A
- HTR2B
- LMNA
- HTR2C
- HTR3A
- HTR6
- IDH1
- KCNH2
- LCK
- NR3C1
- OPRD1
- GMNN
- SIGMAR1
- TP53
- TDP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- AHR
- TOR1A
- SYK
- STK33
- RARA
- NSD2
- NF2L2
- MDR1
- KSYK
- JAK2
- IFNG
- IDHC
- GNRHR
- GLI3
- ESRRA
- CP2D6
- CP2CJ
- ANDR
- TR10B
Drug classes
- Nucleic Acid Synthesis Inhibitors
- Antimetabolites
- Antimetabolites, Antineoplastic
- Antineoplastic Agents
- Antirheumatic Agents
- Immunologic Factors
- Immunosuppressive Agents
- Noxae
- Purine Antimetabolite
ATC classes
- L04A · IMMUNOSUPPRESSANTS
Cross-references
Synonyms
- AZASAN
- AZATHIOPRINE SODIUM
- Azasan
- IMURAN
- Imuran
- BW 57-322
- azathioprine sulfate
- azamune
- azanin
- azathioprin
- azathropine
- azothioprine
- azathioprine sodium
- Azatioprina
- Azathioprinum
- BW-57-322
- NSC-39084
- Azamune
- Azapress
- Berkaprine
- Immunoprin 50
- Jayempi
- Kentaprine
- Oprisine 50
- Azamun
- Azanin
- Azathioprin
- Azathiopurine
- Azatioprin
- Azothioprine
- Ccucol
- Cytostatics
- Immuran
- Imurek
- Imurel
- Methylnitroimidazolylmercaptopurine
- Muran
Reported adverse events
- P
- T-cell lymphoma
- Infection
- Nausea
- Hepatotoxicity
- Leukopenia
- Lymphoma
- Vomiting
- Death
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