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HYDROXYCHLOROQUINE
SynDRA canonical compound SYN0008951 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | TLR9 |
|---|
| Mechanism of action | Anti-malarial agent |
|---|
| Indication | malaria |
|---|
| Disease area | infectious disease |
|---|
All known targets
- TLR7
- TLR9
- ACE2
- CHRM5
- SIGMAR1
- NS3
- KCNH2
- HBA1
- CHRM4
- ADRA1D
- CHRM3
- CHRM2
Mechanisms of action (all sources)
- TLR7 ANTAGONIST
- Toll-like receptor 7 antagonist
- TLR9 ANTAGONIST
- Toll-like receptor 9 antagonist
- ACE inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- ADORA1
- OPRK1
- OPRD1
- NR3C1
- NR1I2
- NPY2R
- NPY1R
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- OPRM1
- PDE3A
- PDE4D
- SLC47A2
- TDP1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SLCO1B3
- SLCO1B1
- SLC6A4
- SLC6A3
- SLC6A2
- SLC47A1
Drug classes
- Antimalarial
- Anti-Infective Agents
- Antimalarials
- Antiparasitic Agents
- Antiprotozoal Agents
- Antirheumatic Agents
- Enzyme Inhibitors
- Antirheumatic Agent
- Anti-malarial agent
- antimalarial agent
ATC classes
Cross-references
Synonyms
- HYDROXYCHLOROQUINE SULFATE
- PLAQUENIL
- Plaquenil
- SOVUNA
- Sovuna
- hydroxychloroquine sulfate
- oxichloroquine
- oxychlorochin
- oxychloroquine
- Hidroxicloroquina
- Polirreumin
- Hidroxicloroquina [INN-Spanish]
- Hydroxychlorochin
- Gen-Hydroxychloroquine 200mg Tablets
- HCQ
- Hydroxychloroguine
- Hydroxychloroquine (INN);Hydroxychloroquine [INN:BAN]
- Hydroxychloroquinum
- Hydroxychloroquinum [INN-Latin]
- Idrossiclorochina
- Idrossiclorochina [DCIT]
- Oxichlorochinum
- Oxichloroquine
- Oxychlorochin
- Oxychloroquine
- Plaquenil (TN)
- Polirreumin (TN)
- Quensyl
- WIN 1258
- 4QWG6N8QKH
- oxichlorochine
- 2-((4-((7-Chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol
- Dolquine
- CHEBI:5801
- NSC4375
- (+-)-hydroxychloroquine
- idroxiclorochina
- RefChem:6447
Reported adverse events
- Cardiomyopathy
- Rash
- Urticaria
- Vertigo
- Stevens-Johnson syndrome
- Fatigue
- Nausea
- Ventricular arrhythmia
- Myopathy
- Retinopathy
- Alopecia
- Eosinophilia
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