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OSI-632
SynDRA canonical compound SYN0008573 — structure-anchored drug synonym record
| Clinical phase | Phase 2 |
|---|
| Primary target(s) | DDR2 | EGFR | FGF2 | KDR |
|---|
| Mechanism of action | kinase inhibitor |
|---|
All known targets
Mechanisms of action (all sources)
- KDR INHIBITOR
- Vascular endothelial growth factor receptor 2 inhibitor
- kinase inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- SYK
- MET
- TAOK1
- PDGFRB
- MST1R
- FER
- LYN
- FGFR1
- FGFR2
- FGFR3
- LCK
- DDR1
- FGFR4
- STK10
- FLT1
- FLT3
- FLT4
- SRC
- FRK
- PLK4
- PTK6
- SLK
- FYN
- PHKG2
- SIK3
- SIK2
- CSNK1E
- COQ8A
- RET
- RIPK2
- PDGFRA
- MINK1
- GSK3B
- MARK2
- VEGFA
- MAP4K5
- MAP4K4
- MAP4K3
- ACVR1B
- MAP4K2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ATXN2
- CP2C9
- VGFR1
- SYUA
- SNCA
- PGFRB
- PGFRA
- NTMT1
- NTM1A
- NSD2
- MK14
- MK09
- M4K5
- M4K4
- M4K2
- KSYK
- IFNB1
- CP3A7
- CP2D6
- VGFR3
Cross-references
Synonyms
- CP-547,632
- CP-547632
- CP-632
- PAN-90806
- PAN90806
- CP 547632
- BFF
- 3-(4-Bromo-2,6-difluorobenzyloxy)-5-(3-(4-pyrrolidin-1-ylbutyl)ureido)isothiazole-4-carboxylic acid amide
- Cp-547632
- CP 547,632
- CP547632
- W1B375O5M2
- RefChem:919128
- DTXCID60102357
- CP547,632
- Kinome_3755
- C20H24BrF2N5O3S
- UNII-W1B375O5M2
- HXHAJRMTJXHJJZ-UHFFFAOYSA-N
- SCHEMBL187261
- GTPL7881
- orb1709995
- BDBM25115
- GLXC-15617
- EX-A11159
- NSC800077
- AKOS016008145
- NSC-800077
- T10870L
- NCGC00263100-01
- NCGC00263100-02
- NCGC00263100-04
- NCGC00263100-05
- AC-25487
- HY-13302
- MS-29834
- CP-547632?
- CS-0003189
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