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HESPERETIN

SynDRA canonical compound SYN0008489 — structure-anchored drug synonym record

All known targets

• CYP1B1
• DGAT1
• CA12
• CA4
• CA7
• DPP4
• GSK3B
• KDM1A
• MTTP
• SOAT1
• SOAT2
• rep

Mechanisms of action (all sources)

• ACAT inhibitor
• DGAT1 INHIBITOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• XDH
• HDAC6
• CYP19A1
• CYP1A1
• PTGS2
• MC3R
• NR1I2
• NR1H3
• NPY1R
• NPC1
• NFE2L2
• MLNR
• MC4R
• MAPK9
• OPRD1
• MAPK8
• MAPK1
• MAOA
• KCNH2
• HTR3A
• HTR2C
• HTR2B
• HTR2A
• HTR1A
• NR3C1
• OPRK1
• HSD17B10
• SLC6A2
• TSHR
• TP53
• TGFBR2
• TDP1
• TBXA2R
• SLCO1B3
• SLCO1B1
• SLC6A4
• SLC6A3
• SLC29A1
• OPRM1
• RAB9A

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• CP1A2
• CP2C9
• CP2CJ
• CP3A4
• IFNG

Cross-references

• PubChem CID: 72281
• ChEMBL: CHEMBL399121
• DrugBank: DB01094
• ChEBI: CHEBI:28230
• KEGG: C01709
• RxNorm: 1314255
• PDB: 6JP
• Wikipedia: Hesperetin
• TTD: D07MGA
• LINCS BRD: BRD-K30553453

Synonyms

• hesperitin
• (-)-hesperetin
• Eriodictyol 4'-monomethyl ether
• Hesperitin
• FEMA NO. 4313
• NSC-57654
• Hesperin
• TNP00238
• YSO2
• Cyanidanon 4'-methyl ether 1626
• Flavanone, 3',5,7-trihydroxy-4'-methoxy-(VAN)
• Flavanone, 3',5,7-trihydroxy-4'-methoxy-(VAN) (8CI)
• (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-one
• (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one
• (S)-2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone
• (S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
• 3',5,7-Trihydroxy-4'-methoxyflavanone
• 3',5,7-Trihydroxy-4-methoxyflavanone
• 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)-(9CI)
• 5,7,3'-Trihydroxy-4'-methoxyflavanone
• (-)-(S)-hesperetin
• NSC 57654
• Q9Q3D557F1
• CHEBI:28230
• Flavanone, 3',5,7-trihydroxy-4'-methoxy-
• RefChem:783778
• DTXCID702319
• (S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one
• (S)-Hesperetin
• MFCD00075646
• Prestwick_908
• EINECS 208-290-2
• Hesperitine
• UNII-Q9Q3D557F1
• RS-Hesperetin
• 6JP
• (+-)-Hesperetin
• 4'-Methoxy-3',5,7-trihydroxyflavanone