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ZALEPLON
SynDRA canonical compound SYN0008486 — structure-anchored drug synonym record
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | GABRA1 |
|---|
| Mechanism of action | Benzodiazepine receptor agonist |
|---|
All known targets
- GABRA1
- GABRG2
- GABRB1
- GABRA2
- GABRB2
- GABRB3
Mechanisms of action (all sources)
- Benzodiazepine receptor agonist
- GABRA1 POSITIVE ALLOSTERIC MODULATOR
- GABA A receptor alpha-1/beta-1/gamma-2 positive allosteric modulator
- GABRG2 POSITIVE ALLOSTERIC MODULATOR
- GABRB1 POSITIVE ALLOSTERIC MODULATOR
- GABRA1 MODULATOR
- GABRB3 POSITIVE ALLOSTERIC MODULATOR
- GABRA2 POSITIVE ALLOSTERIC MODULATOR
- GABRB2 POSITIVE ALLOSTERIC MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PDE3A
- ACHE
- NPY1R
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LCK
- KDM4E
- KCNH2
- KAT2A
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- HDAC6
- MMP9
- NPY2R
- ADORA1
- NR1I2
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SLC6A4
- SLC6A3
- SLC6A2
- SLC29A1
- SIGMAR1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- GABA A Agonists
- Anticonvulsants
- Central Nervous System Agents
- Central Nervous System Depressants
- GABA Agents
- GABA Modulators
- Hypnotics and Sedatives
- Neurotransmitter Agents
- gamma-Aminobutyric Acid A Receptor Agonist
ATC classes
- N05C · HYPNOTICS AND SEDATIVES
Cross-references
Synonyms
- SONATA
- sonata
- ZAL-846
- CL 284,846
- CL-284846
- Zaleplone
- Zerene
- L-846
- L846
- LJC-10846
- LJC10846
- SKP-1041
- Sonata
- Zaleplon civ
- Zalaplon
- AZ-007
- CL284,846
- Sonata (TN)
- Staccato-zaleplon
- Starnoc (TN)
- Zaleplon [USAN:INN]
- Zaleplon (JAN/USAN/INN)
- CL 284846
- ZAL 846
- DEA No. 2781
- S62U433RMH
- CHEBI:10102
- NCGC00160525-01
- SMR000238180
- CAS-151319-34-5
- UNII-S62U433RMH
- Zaleplon AP
- Zaleplon [USAN:USP:INN:BAN]
- ZALEPLON [USAN]
- ZALEPLON [INN]
- ZALEPLON [JAN]
- ZALEPLON [MI]
Reported adverse events
- Amnesia
- Asthenia
- Colitis
- Dizziness
- Epistaxis
- Hallucination
- Headache
- Hyperacusis
- Hypertonia
- Malaise
- Nausea
- Parosmia
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