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VARDENAFIL
SynDRA canonical compound SYN0008483 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PDE5A |
|---|
| Mechanism of action | Phosphodiesterase inhibitor |
|---|
| Indication | erectile dysfunction |
|---|
| Disease area | urology |
|---|
All known targets
- PDE5A
- CYP2C19
- PDE4A
- PDE6H
- PDE6G
- PDE6A
- PDE4D
- PDE4C
- PDE4B
- PDE3B
- CYP2C8
- PDE3A
Mechanisms of action (all sources)
- Phosphodiesterase inhibitor
- PDE5A INHIBITOR
- Phosphodiesterase 5A inhibitor
- PDE5A BINDER
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ADORA1
- ABL1
- PGR
- HRH3
- HTR1A
- HTR2B
- KCND3
- KCNH2
- KDR
- MAOA
- MAPK1
- OPRM1
- PLIN1
- HDAC6
- PTGS1
- PTH1R
- SAMHD1
- SLC6A2
- SLC6A3
- SLC6A4
- TBXA2R
- TDP1
- HNF4A
- GSK3B
- ACHE
- CDK2
- ADORA3
- ADRA1A
- ADRA2A
- AR
- AURKA
- BRD4
- BRPF1
- CACNA1C
- CHRM1
- GMNN
- CHRM2
- CSNK1D
- CYP3A4
- DRD1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ATXN2
- CFTR
- PLIN5
- PDE7B
- PDE7A
- PDE6D
- PDE6C
- PDE6B
- PDE1C
- NTMT1
- NTM1A
- NR1I2
- NF2L2
- GLI3
- CP3A7
- CP3A4
- CP2C9
- TP53
Drug classes
- Phosphodiesterase 5 Inhibitors
- Cardiovascular Agents
- Enzyme Inhibitors
- Phosphodiesterase Inhibitors
- Urological Agents
- Vasodilator Agents
- Phosphodiesterase 5 Inhibitor
ATC classes
Cross-references
Synonyms
- LEVITRA
- Levitra
- STAXYN
- Staxyn
- VARDENAFIL HYDROCHLORIDE
- vardenafil hydrochloride hydrate
- vardenafil dihydrochloride
- vivanza
- vardenafil hydrochloride
- vardenafil hydrochloride trihydrate
- levitra
- vardenafil HCl
- Vivanza
- BAY-389456
- BAY38-9456
- VDN
- Levitra (TN)
- VARDENAFIL, LEVITRA
- Vardenafil (INN)
- UCE6F4125H
- CHEBI:46295
- Vardenafilum
- RefChem:57722
- DTXCID5028293
- G04BE09
- Vardenafil ODT
- HSDB 7304
- SR-05000001442
- NCGC00167533-01
- UNII-UCE6F4125H
- Vardenafil [USAN:INN:BAN]
- Vardenafil (Standard)
- VARDENAFIL [MI]
- VARDENAFIL [INN]
- Vardenafil (USAN/INN)
- VARDENAFIL [HSDB]
- VARDENAFIL [USAN]
- VARDENAFIL [VANDF]
Reported adverse events
- Headache
- Back pain
- Dizziness
- Nausea
- Dyspepsia
- Priapism
- Flushing
- Rhinitis
- Seizure
- Sinusitis
- Sudden hearing loss
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