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PROPYLTHIOURACIL
SynDRA canonical compound SYN0008440 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | TPO |
|---|
| Mechanism of action | Thyroid peroxidase inhibitor |
|---|
| Indication | goiter | Grave's disease | hyperthyroidism |
|---|
| Disease area | endocrinology |
|---|
All known targets
Mechanisms of action (all sources)
- Thyroid peroxidase inhibitor
- TPO INHIBITOR
- DIO1 INHIBITOR
- Type I iodothyronine deiodinase (Type-I 5'-deiodinase) (DIOI) (Type 1 DI) (5DI) inhibitor
- TAS2R38 AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR1
- LPO
- ACHE
- MAPK1
- NR1I2
- NPY2R
- NPY1R
- NFE2L2
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAOA
- OPRD1
- LCK
- KCNH2
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- NR3C1
- OPRK1
- HDAC6
- OPRM1
- VDR
- TSHR
- TDP1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Antimetabolites
- Antithyroid Agents
- Hormone Antagonists
- Noxae
- Thyroid Hormone Synthesis Inhibitors
- Thyroid Hormone Synthesis Inhibitor
ATC classes
- H03B · ANTITHYROID PREPARATIONS
Cross-references
Synonyms
- 6-n-Propylthiouracil
- procasil
- propacil
- prothiurone
- Propylthiouracile
- Propiltiouracilo
- Thyreostat ii
- NSC-6498
- NSC-70461
- Propacil
- Prothyran
- 6-propyl-2 thiouracil
- Prothiurone
- Procasil
- Propycil
- Thiuragyl
- Protiural
- Prothiucil
- Prothycil
- Propyl-Thiorist
- Propyl-Thyracil
- 6-N-Propylthiouracil
- Propythiouracil
- Propilthiouracil
- Propyl-Thiorit
- Propylthiorit
- 6-Propylthiouracil
- Thyreostat II
- 6-N-Propyl-2-thiouracil
- 6-Thio-4-propyluracil
- PTU (thyreostatic)
- Propylthiouracilum
- 4-Propyl-2-thiouracil
- Propiltiouracile
- PROPYL THIOURACIL
- Propiltiouracile [DCIT]
- Thyreos tat ii
Reported adverse events
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