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METHIMAZOLE
SynDRA canonical compound SYN0008363 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | TPO |
|---|
| Mechanism of action | Anti-thyroid agent |
|---|
| Indication | hyperthyroidism |
|---|
| Disease area | endocrinology |
|---|
All known targets
Mechanisms of action (all sources)
- TPO INHIBITOR
- Thyroid peroxidase inhibitor
- TAS2R38 AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR2
- PTGS1
- ACHE
- MAOA
- NPY2R
- NPY1R
- MMP9
- MMP1
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- LMNA
- OPRD1
- LCK
- KDM4A
- KCNH2
- HTR6
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- NR3C1
- OPRK1
- HDAC6
- OPRM1
- TDP1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SMN1
- SLCO1B3
- SLCO1B1
- SLC6A4
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CP2C9
- GPR32
- HSPB1
- JUN
- NF2L2
Drug classes
- Antithyroid Agents
- Hormone Antagonists
- Thyroid Hormone Synthesis Inhibitors
- Thyroid Hormone Synthesis Inhibitor
- Anti-thyroid agent
- antithyroid agent
ATC classes
- H03B · ANTITHYROID PREPARATIONS
Cross-references
Synonyms
- Felanorm
- Felimazole
- TAPAZOLE
- thiamazole
- methylimidazolethiol
- thyrozol
- thymidazole
- thymidazol
- thycapzol
- tapazole
- methymazol
- Thiamazole
- Thiamazol
- Tiamazol
- Mercaptizole
- NSC-38608
- Favistan
- Tapazole
- 2-Mercapto-1-methylimidazole
- Mercazolyl
- 1-Methylimidazole-2-thiol
- Thymidazole
- Mercazole
- Methimazol
- Thymidazol
- Metazolo
- Thycapzol
- Metothyrine
- Metothyrin
- Merkazolil
- Mercaptazole
- Strumazol
- Basolan
- Thycapsol
- Metotirin
- Danantizol
- Thacapzol
Reported adverse events
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