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OMEPRAZOLE
SynDRA canonical compound SYN0008013 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ATP4A |
|---|
| Mechanism of action | ATPase inhibitor |
|---|
| Indication | heartburn |
|---|
| Disease area | gastroenterology |
|---|
All known targets
- ATP4A
- ATP4B
- CLCN2
- CYP1A2
- CYP2C19
- ABCB1
- ABCG2
- CYP2C9
- CYP3A4
- DDAH1
- ENGASE
- FASN
Mechanisms of action (all sources)
- ATPase inhibitor
- ATP4A INHIBITOR
- Potassium-transporting ATPase inhibitor
- ATP4B INHIBITOR
- CLCN2 MODULATOR
- proton pump inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ATP12A
- AHR
- ADORA3
- ESR2
- PTGS1
- MMP1
- MC3R
- MC4R
- MC5R
- MCL1
- MDH1
- ABCB11
- MAPT
- NFE2L2
- NPY1R
- NPY2R
- NR1H4
- NR3C1
- OPRD1
- OPRK1
- MMP9
- MAPK3
- PDE3A
- MAPK14
- MAPK1
- MAOA
- LCK
- KDR
- KDM4E
- KDM4A
- KCNH2
- KAT2A
- IDE
- HTT
- HTR6
- HTR2C
- HTR2B
- OPRM1
- PDE5A
- PDE4A
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACM1
- NTM1A
- KMT2A
- LOX12
- MDR1
- MPI
- NF2L2
- NR1I2
- NTMT1
- ACM4
- PHGDH
- PPARG
- PRGR
- PRMT1
- RARA
- TRFR
- ITA4
- HXA9
- HSPB1
- GPX4
- GPX1
- GCR
- ESRRA
- CP3A7
- CP3A4
- CP2D6
- CP2CJ
- CP2C9
- CP1A2
- CIB1
- ANDR
- ALR
- ALOX12
- WDR5
Drug classes
- Proton Pump Inhibitors
- Proton Pump Inhibitor
- Anti-Ulcer Agents
- Enzyme Inhibitors
- Gastrointestinal Agents
- Cytochrome P450 2C19 Inhibitors
ATC classes
- A02B · DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
- ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Cross-references
Synonyms
- KONVOMEP
- Konvomep
- MAGNESIUM HYDROXIDE AND OMEPRAZOLE AND SODIUM BICARBONATE
- OMECLAMOX-PAK
- OMEPRAZOLE AND SODIUM BICARBONATE
- OMEPRAZOLE MAGNESIUM
- PRILOSEC
- PRILOSEC OTC
- Prilosec
- TALICIA
- YOSPRALA
- omeprazole sodium
- omeprazole magnesium
- omeprazole sodium bicarbonate
- Omeprazol
- H-168/68
- NSC-751450
- NSC-759192
- Antra
- Losec
- Losec mups
- Mezzopram
- Mopral
- Omeprazole component of konvomep
- Omeprazole component of pa-32540
- Omeprazole component of yosprala
- Omeprazole component of zegerid
- Omeran
- Zanprol
- Losec (TN)
- Omeprazon
- Audazol
- Omapren
- Omepral
- Parizac
- Zegerid
- Miol
Reported adverse events
- GI bleed
- Perforation
- Ulceration
- Elderly
- Hypersensitivity
- Stevens-Johnson syndrome
- Tinnitus
- Agranulocytosis
- Pancreatitis
- Headache
- Fracture
- Chest pain
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