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NIFEDIPINE
SynDRA canonical compound SYN0008011 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CACNA2D1 |
|---|
| Mechanism of action | Calcium channel blocker |
|---|
| Indication | chronic stable angina | vasospastic angina |
|---|
| Disease area | cardiology |
|---|
All known targets
- CACNA1D
- CACNA1F
- CACNA1S
- CACNA1C
- GLRA3
- GLRB
- GLRA1
- KCNA5
- KCNA1
- NR1I2
- CACNA1H
- CACNA2D1
Mechanisms of action (all sources)
- Calcium channel blocker
- CACNA1C BLOCKER
- Voltage-gated L-type calcium channel blocker
- CACNA1S BLOCKER
- CACNA1D BLOCKER
- CACNA1F BLOCKER
- CACNA1D ANTAGONIST
- CACNA1F ANTAGONIST
- GLRA1 ANTAGONIST
- GLRA3 ANTAGONIST
- GLRB ANTAGONIST
- KCNA5 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HTR2B
- CHRM4
- ESR2
- DRD3
- DRD2
- DRD1
- CHRM2
- CHRM3
- CHRM1
- CHRM5
- CYP2J2
- CYP2C9
- CYP2C19
- MTOR
- NTSR1
- OPRD1
- OPRK1
- NR3C1
- NR1H4
- NPY2R
- NPY1R
- NFKB1
- NFE2L2
- MPHOSPH8
- PDE1C
- MAPK1
- HTR6
- IDH1
- KDM4A
- KDM4E
- KMT2A
- LCK
- LMNA
- MAOA
- MAPK14
- MMP9
- MAPK3
- MAPT
- MBNL1
- MC3R
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- AHR
- ANDR
- MDM2
- MDM4
- MDR1
- MK01
- MPI
- NF2L2
- NPR2
- NTM1A
- PHGDH
- PIP4K2A
- PLIN1
- PLIN5
- PRGR
- PRKN
- RARA
- S12A5
- SMAD2
- KSYK
- KCNJ1
- GLI3
- CP2D6
- BARD1
- BRCA1
- CAC1B
- CP19A
- CP1A2
- CP2C9
- CP2CJ
- CP3A4
- GEMI
- CP3A7
- CREB1
- CTBP1
- ESRRA
- FUMH
- G3P
- GCR
- SYK
Drug classes
- Calcium Channel Antagonists
- Dihydropyridine Calcium Channel Blocker
- Calcium Channel Blockers
- Calcium-Regulating Hormones and Agents
- Cardiovascular Agents
- Membrane Transport Modulators
- Reproductive Control Agents
- Tocolytic Agents
- Vasodilator Agents
ATC classes
- C08C · SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
- BETA BLOCKING AGENTS, OTHER COMBINATIONS
- CALCIUM CHANNEL BLOCKERS AND DIURETICS
Cross-references
Synonyms
- ADALAT
- ADALAT CC
- AFEDITAB CR
- Afeditab CR
- PROCARDIA
- PROCARDIA XL
- Procardia
- BAY A1040
- nedipin
- fedipin
- Nifedipino
- Coracten
- Nifedipine hydrochloride
- Nifedipine slow release
- Nifedipinum
- BAY-A-1040
- NSC-757242
- Adalat
- Adalat a.r.
- Adalat cc
- Adalat ic
- Adalat la 20
- Adalat la 30
- Adalat la 60
- Adalat ret
- Adalate lp
- Adanif xl
- Adipine mr 10
- Adipine mr 20
- Adipine xl
- Afeditab cr
- Angiopine 10
- Angiopine 40 la
- Angiopine 5
- Angiopine mr 10
- Angiopine mr 20
- Calanif
Reported adverse events
- Syncope
- Hypotension
- Myocardial infarction
- Ventricular arrhythmia
- Dizziness
- Headache
- Nausea
- Gastrointestinal obstruction
- Flushing
- Nasal congestion
- Nervousness
- Constipation
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