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FLUOCINONIDE
SynDRA canonical compound SYN0008001 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | NR3C1 | SERPINA6 | SMO |
|---|
| Mechanism of action | glucocorticoid receptor agonist |
|---|
| Indication | eczema | seborrheic dermatitis |
|---|
| Disease area | dermatology |
|---|
All known targets
- NR3C1
- ESRRA
- ESRRB
- ESRRG
- PGR
- SERPINA6
- SMO
Mechanisms of action (all sources)
- Corticosteroid agonist
- NR3C1 AGONIST
- NR3C1 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- AR
- DRD1
- IDH1
- MMP1
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LCK
- KDR
- KCNH2
- ACHE
- NPY1R
- HTR6
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- HIF1A
- HDAC6
- MMP9
- NPY2R
- FLT1
- OPRD1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SMAD3
- SLCO1B3
- SLCO1B1
- SLC6A4
- SLC6A3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- KSYK
- NSD2
- PRGR
- SYK
- WEE1
Drug classes
- Corticosteroid Hormone Receptor Agonists
- Corticosteroid
- Anti-Allergic Agents
- Anti-Inflammatory Agents
- Glucocorticoids
- Hormones
ATC classes
- C05A · AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
- D07A · CORTICOSTEROIDS, PLAIN
- CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
- S01B · ANTIINFLAMMATORY AGENTS
- S02B · CORTICOSTEROIDS
- CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS
- ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
- CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Cross-references
Synonyms
- FLUOCINONIDE EMULSIFIED BASE
- LIDEX
- LIDEX-E
- VANOS
- Vanos
- flucetonide
- fluocinolide
- fluocinolide acetate
- fluocinolone acetonide acetate
- Fluocinonida
- Fluocinolide
- NSC-101791
- Fluocinonide emulsified base
- Lidex
- Lidex-e
- Metosyn
- Metosyn fapg
- Bestasone
- Biscosal
- Cortalar
- Fluocinonido
- Fluocinonidum
- Fluonex
- Fluzon
- Lonide
- Lyderm;Metosyn
- Straderm
- Topsymin
- Topsyn
- Fluocinolide acetate
- Fluocinolone acetonide acetate
- Fluocinonide Emulsified Base
- Fluocinonide FAPG
- Synalar acetate
- Fluocinolone acetonide 21-acetate
- Fluocinonido [INN-Spanish]
- Fluocinonidum [INN-Latin]
Reported adverse events
- Milia
- Hypertrichosis
- Perioral dermatitis
- Dermatitis
- Headache
- Ear infection
- Folliculitis
- Nasopharyngitis
- Rash
- Telangiectasia
- Cushing's syndrome
- Skin atrophy
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