← SynDRA

DIGITOXIN

SynDRA canonical compound SYN0007993 — structure-anchored drug synonym record

All known targets

• ATP1A1
• ATP1A2
• ATP1A3
• ATP1B1
• ATP1B2
• ATP1B3
• ATP1A4
• FXYD2
• KCNH2
• STAT3

Mechanisms of action (all sources)

• ATPase inhibitor
• ATP1A1 INHIBITOR
• ATP1B2 INHIBITOR
• ATP1B1 INHIBITOR
• ATP1A2 INHIBITOR
• ATP1B3 INHIBITOR
• ATP1A3 INHIBITOR
• ATP1A4 INHIBITOR
• FXYD2 INHIBITOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• ABCB11
• NPY1R
• SLCO4C1
• ESR1
• NPY2R
• OPRD1
• NR3C1
• NR1H4
• MC4R
• OPRK1
• NPC1
• OPRM1
• NFE2L2
• MMP9
• PDE3A
• MMP1
• MC5R
• MC3R
• PDE5A
• MAPT
• MAPK3
• MAPK14
• MAPK1
• MAOB
• MAOA
• LMNA
• LCK
• KDR
• IDH1
• HTR6
• HTR2C
• PDE4A
• ABCB1
• HTR2B
• PPARD
• VDR
• TP53
• TOP2B
• TOP2A
• THRB

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• A4
• ANDR
• TNF10
• SYK
• STK33
• SC6A3
• PTBP1
• NSD2
• NOD2
• NOD1
• NF2L2
• MDR1
• KSYK
• KLF5
• INS
• IL1B
• IFNB1
• IDHC
• HLAB
• GEMI
• GCR
• ESRRA
• ATXN2
• TSHR

Drug classes

• Anti-Arrhythmia Agents
• Cardiotonic Agents
• Cardiovascular Agents
• Enzyme Inhibitors
• Protective Agents

ATC classes

• C01A · CARDIAC GLYCOSIDES

Cross-references

• PubChem CID: 441207
• ChEMBL: CHEMBL254219
• DrugBank: DB01396
• ChEBI: CHEBI:28544
• KEGG: D00297
• RxNorm: 3403
• PDB: F9R
• Wikipedia: Digitoxin
• TTD: D0M3QP
• LINCS BRD: BRD-K59873006

Synonyms

• CRYSTODIGIN
• digitoxoside
• cardidigin
• cardigin
• carditoxin
• coramedan
• cristapurat
• crystodigin
• digicor
• digipural
• digisidin
• digitophyllin
• digitoxigenin tridigitoxoside
• myodigin
• purpurid
• tradigal
• unidigin
• Digitoxine
• Digitoxina
• Cristapurat
• Digitalin, crystalline
• Digitophyllin
• Digitoxinum
• Glucodigin
• Lanatoxin
• Purpurid
• Tradigal
• Crystodigin
• NSC-7529
• Digimerck
• Nativelle digitaline
• Acedoxin
• Asthenthilo
• Cardidigin
• Cardigin
• Cardiolanata
• Carditalin
• Carditoxin