CORTISONE

SynDRA canonical compound SYN0007992 — structure-anchored drug synonym record

Clinical phase	Launched
Primary target(s)	NR3C1
Mechanism of action	glucocorticoid receptor agonist
Indication	eczema \| joint inflammation \| psoriasis \| rheumatoid arthritis \| ulcerative colitis \| ulcerative colitis, rheumatoid arthritis, psoriasis, joint inflammation, eczema
Disease area	dermatology \| dermatology \| gastroenterology \| gastroenterology, rheumatology, dermatology \| rheumatology \| rheumatology

All known targets

NR3C1
ANXA1
NOS2
NR3C2
ESRRA
ESRRB
ESRRG
SERPINA6
KCNA1
SHBG
SLC47A1
FNTA

Mechanisms of action (all sources)

NR3C1 AGONIST
Corticosteroid agonist
NR3C1 MODULATOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

ANDR
CP2CJ
CP3A7
GCR
GLI3
PRGR
RARA

Drug classes

Anti-Inflammatory Agents
Corticosteroid Hormone Receptor Agonists
Corticosteroid
Dermatologic Agents

ATC classes

S01B · ANTIINFLAMMATORY AGENTS
A07E · INTESTINAL ANTIINFLAMMATORY AGENTS
S01C · ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
D07A · CORTICOSTEROIDS, PLAIN
D07X · CORTICOSTEROIDS, OTHER COMBINATIONS
A01A · STOMATOLOGICAL PREPARATIONS
R01A · DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
C05A · AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
H02A · CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
S02B · CORTICOSTEROIDS
CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS

Cross-references

PubChem CID: 222786
ChEMBL: CHEMBL1499
DrugBank: DB14681
ChEBI: 16962
KEGG: C00762
RxNorm: 2878
PDB: UQC
Wikipedia: Cortisone
TTD: D0IX6I
LINCS BRD: BRD-K43736954

Synonyms

Reported adverse events

Ototoxicity
Cushingoid
Vertigo
Perioral dermatitis
Epidural lipomatosis
Central serous chorioretinopathy
Hypertrichosis
Leukocytosis
Acne
Glaucoma
Milia
Skin irritation

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